J Invest Dermatol. 2006 Jun;126(6):1205-6.

PSORS1: linking genetics and immunology.

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University of Michigan Medical Center, Department of Dermatology, Ann Arbor, Michigan, USA. jelder@umich.edu

Abstract

Previous studies have localized the psoriasis susceptibility 1 (PSORS1) locus to the proximal major histocompatibility complex class I region, but approximately a dozen genes in the candidate region have thus far been genetically inseparable. According to a team of researchers in the United States and Germany, the primary genetic association has now been worked out, implicating HLA-Cw6 "after all." The results integrate genetics and immunology, further reinforcing our emerging understanding of psoriasis.

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