Hippocampus. 1991 Apr;1(2):181-92.

Learning-related patterns of CA1 spike trains parallel stimulation parameters optimal for inducing hippocampal long-term potentiation.

Otto T, Eichenbaum H, Wiener SI, Wible CG.

Source

Department of Biological Sciences, Wellesley College, MA 02181.

Abstract

Recent studies have revealed 3 stimulation parameters that together comprise the temporal pattern of neuronal activation optimal for the induction of hippocampal LTP: high-frequency bursts, activity 100-200 ms prior to a burst, and burst delivery in phase with the ongoing hippocampal theta rhythm. The present paper reports that these 3 aspects of patterned neural activity, collectively referred to as "theta-bursting," are characteristic of the spike trains of CA1 pyramidal cells in rats during the sampling and analysis of learning cues in an odor discrimination task and during performances of a spatial memory task. In contrast, theta-bursting occurs relatively infrequently during behavioral events less directly related to task-relevant mnemonic processing. These findings suggest that the optimal conditions for the induction of LTP occur naturally in behaving animals, time-locked to behavioral events critical to learning.

PMID:: 1669292; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Grant Support

Publication Types

MeSH Terms

Grant Support

NS26402/NS/NINDS NIH HHS/United States

LinkOut - more resources

Supplemental Content

Save items

Related citations in PubMed

Induction and transient suppression of long-term potentiation in the peri- and postrhinal cortices following theta-related stimulation of hippocampal field CA1. [Brain Res. 1998]
Induction and transient suppression of long-term potentiation in the peri- and postrhinal cortices following theta-related stimulation of hippocampal field CA1.
Cousens G, Otto TA. Brain Res. 1998 Jan 5; 780(1):95-101.
Stimulation on the positive phase of hippocampal theta rhythm induces long-term potentiation that can Be depotentiated by stimulation on the negative phase in area CA1 in vivo. [J Neurosci. 1997]
Stimulation on the positive phase of hippocampal theta rhythm induces long-term potentiation that can Be depotentiated by stimulation on the negative phase in area CA1 in vivo.
Hölscher C, Anwyl R, Rowan MJ. J Neurosci. 1997 Aug 15; 17(16):6470-7.
EPSP-spike potentiation during primed burst-induced long-term potentiation in the CA1 region of rat hippocampal slices. [Neuroscience. 1994]
EPSP-spike potentiation during primed burst-induced long-term potentiation in the CA1 region of rat hippocampal slices.
Pugliese AM, Ballerini L, Passani MB, Corradetti R. Neuroscience. 1994 Oct; 62(4):1021-32.
Review Hippocampal long-term depression: master or minion in declarative memory processes? [Trends Neurosci. 2007]
Review Hippocampal long-term depression: master or minion in declarative memory processes?
Kemp A, Manahan-Vaughan D. Trends Neurosci. 2007 Mar; 30(3):111-8. Epub 2007 Jan 17.
Review Comparative aspects of hippocampal and neocortical long-term potentiation. [J Neurosci Methods. 1989]
Review Comparative aspects of hippocampal and neocortical long-term potentiation.
Teyler TJ. J Neurosci Methods. 1989 May; 28(1-2):101-8.

See reviews... See all...

Cited by 32 PubMed Central articles

CX(3)CR1 deficiency alters hippocampal-dependent plasticity phenomena blunting the effects of enriched environment. [Front Cell Neurosci. 2011]
CX(3)CR1 deficiency alters hippocampal-dependent plasticity phenomena blunting the effects of enriched environment.
Maggi L, Scianni M, Branchi I, D'Andrea I, Lauro C, Limatola C. Front Cell Neurosci. 2011; 5:22. Epub 2011 Oct 19.
BDNF signaling during learning is regionally differentiated within hippocampus. [J Neurosci. 2010]
BDNF signaling during learning is regionally differentiated within hippocampus.
Chen LY, Rex CS, Pham DT, Lynch G, Gall CM. J Neurosci. 2010 Nov 10; 30(45):15097-101.
Hippocampal θ dysfunction after lateral fluid percussion injury. [J Neurotrauma. 2010]
Hippocampal θ dysfunction after lateral fluid percussion injury.
Fedor M, Berman RF, Muizelaar JP, Lyeth BG. J Neurotrauma. 2010 Sep; 27(9):1605-15.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Learning-related patterns of CA1 spike trains parallel stimulation parameters op...
Learning-related patterns of CA1 spike trains parallel stimulation parameters optimal for inducing hippocampal long-term potentiation.
Hippocampus. 1991 Apr ;1(2):181-92.

PubMed
Math5 is required for both early retinal neuron differentiation and cell cycle p...
Math5 is required for both early retinal neuron differentiation and cell cycle progression.
Dev Biol. 2006 Jul 15 ;295(2):764-78. Epub 2006 Apr 7 .

PubMed
Actions of norepinephrine in the rat hippocampus.
Actions of norepinephrine in the rat hippocampus.
Prog Brain Res. 1991 ;88:323-30.

PubMed
Memory reconsolidation: sensitivity of spatial memory to inhibition of protein s...
Memory reconsolidation: sensitivity of spatial memory to inhibition of protein synthesis in dorsal hippocampus during encoding and retrieval.
Neuron. 2006 May 4 ;50(3):479-89.

PubMed
The persistent expression of a highly polysialylated NCAM in the dentate gyrus o...
The persistent expression of a highly polysialylated NCAM in the dentate gyrus of the adult rat.
Neurosci Res. 1991 Dec ;12(4):503-13.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Learning-related patterns of CA1 spike trains parallel stimulation parameters optimal for inducing hippocampal long-term potentiation.

Source

Abstract

Publication Types, MeSH Terms, Grant Support

Publication Types

MeSH Terms

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Libraries

Supplemental Content

Save items

Related citations in PubMed

Cited by 32 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information