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    Cancer Genet Cytogenet. 2006 Apr 15;166(2):180-5.

    A Ph-negative chronic myeloid leukemia with a complex BCR/ABL rearrangement and a t(6;9)(p21;q34.1).

    Todorić-Zivanović B, Marisavljević D, Surace C, Cemerikić V, Marković O, Krtolica K, Tatomirović Z, Cikota B, Magić Z, Rocchi M.

    Source

    Military Medical Academy, Bezanijska Kosa, Belgrade, Serbia and Montenegro. btodoric@hotmail.com

    Abstract

    Chronic myeloid leukemia (CML) is a clonal malignant disorder of a pluripotent hematopoetic stem cell characterized by the presence of the Philadelphia (Ph) chromosome in more than 90% of patients. Cryptic or "masked" BCR/ABL gene rearrangements may be found in cases with a normal karyotype and in cases with the complex karyotype, in which typical t(9;22) is not visible at the microscopic level. Those rearrangements can now be detected by fluorescence in situ hybridization. Here, we report on a novel and complex Ph chromosome-negative CML case with a t(6;9)(p21;q34.1) in which the BCR/ABL fusion gene is located at 6p21.

    PMID:
    16631477
    [PubMed - indexed for MEDLINE]

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      • FISH mapping of Philadelphia negative BCR/ABL1 positive CML. [Mol Cytogenet. 2008]
        FISH mapping of Philadelphia negative BCR/ABL1 positive CML.
        Virgili A, Brazma D, Reid AG, Howard-Reeves J, Valgañón M, Chanalaris A, De Melo VA, Marin D, Apperley JF, Grace C, et al. Mol Cytogenet. 2008 Jul 18; 1:14. Epub 2008 Jul 18.

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