Genes Dev. 1991 Nov;5(11):1935-45.

Transcription from a TATA-less promoter requires a multisubunit TFIID complex.

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Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720.

Abstract

In eukaryotes, the TATA box-binding protein (TBP) is responsible for nucleating assembly of the transcription initiation machinery. Here, we report that a TFIID complex containing TBP is essential for transcription even at a promoter that lacks a TATA box. Immunopurification of TFIID reveals that the active species in reconstituting TATA-less transcription is a multisubunit complex consisting of TBP and many TBP-associated factors (TAFs).

PMID:: 1657708; [PubMed - indexed for MEDLINE]

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