Science. 1991 Sep 27;253(5027):1550-3.

Transcriptional repression mediated by the WT1 Wilms tumor gene product.

Madden SL, Cook DM, Morris JF, Gashler A, Sukhatme VP, Rauscher FJ 3rd.

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Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104.

Abstract

The wt1 gene, a putative tumor suppressor gene located at the Wilms tumor (WT) locus on chromosome 11p13, encodes a zinc finger-containing protein that binds to the same DNA sequence as EGR-1, a mitogen-inducible immediate-early gene product that activates transcription. The transcriptional regulatory potential of WT1 has not been demonstrated. In transient transfection assays, the WT1 protein functioned as a repressor of transcription when bound to the EGR-1 site. The repression function was mapped to the glutamine- and proline-rich NH2-terminus of WT1; fusion of this domain to the zinc finger region of EGR-1 converted EGR-1 into a transcriptional repressor.

PMID:: 1654597; [PubMed - indexed for MEDLINE]

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Human platelet-derived growth factor A chain is transcriptionally repressed by the Wilms tumor suppressor WT1. [Proc Natl Acad Sci U S A. 1992]
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