Proc Natl Acad Sci U S A. 1991 Sep 15;88(18):8159-63.

Neurotrophic activity of platelet-derived growth factor (PDGF): Rat neuronal cells possess functional PDGF beta-type receptors and respond to PDGF.

Smits A, Kato M, Westermark B, Nistér M, Heldin CH, Funa K.

Source

Ludwig Institute for Cancer Research, Biomedical Center, Uppsala, Sweden.

Abstract

The different isoforms of PDGF bind with different affinities to two different receptor types. Previously, these receptors have been demonstrated mainly on mesenchymal and glial cells. We show here that PDGF beta-type receptors are present also on rat brain neurons in vivo as well as in vitro. Immunohistochemical analysis of a sequentially sectioned brain of a newborn rat revealed the presence of PDGF beta receptors in neurons throughout the central nervous system. These beta-receptor-bearing cells were shown to contain neurofilaments by double immunofluorescence staining. Furthermore, the PDGF-BB isoform bound to cells in a neuron-enriched culture from newborn rat brains and induced c-Fos protein in these cells. Continuous PDGF-BB treatment of primary rat brain cell cultures resulted in outgrowth of neurites and prolonged survival. These results indicate a neurotrophic effect of PDGF-BB.

PMID:: 1654560; [PubMed - indexed for MEDLINE]
PMCID:: PMC52466

Free PMC Article

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Libraries

LinkOut Holdings

Supplemental Content

Save items

Related citations in PubMed

Specific effects of platelet derived growth factor (PDGF) on fetal rat and human dopaminergic neurons in vitro. [Exp Brain Res. 1995]
Specific effects of platelet derived growth factor (PDGF) on fetal rat and human dopaminergic neurons in vitro.
Othberg A, Odin P, Ballagi A, Ahgren A, Funa K, Lindvall O. Exp Brain Res. 1995; 105(1):111-22.
PDGF-BB exerts trophic activity on cultured GABA interneurons from the newborn rat cerebellum. [Eur J Neurosci. 1993]
PDGF-BB exerts trophic activity on cultured GABA interneurons from the newborn rat cerebellum.
Smits A, Ballagi AE, Funa K. Eur J Neurosci. 1993 Aug 1; 5(8):986-94.
Coexpression of the platelet-derived growth factor (PDGF) B chain and the PDGF beta receptor in isolated pancreatic islet cells stimulates DNA synthesis. [Proc Natl Acad Sci U S A. 1990]
Coexpression of the platelet-derived growth factor (PDGF) B chain and the PDGF beta receptor in isolated pancreatic islet cells stimulates DNA synthesis.
Welsh M, Claesson-Welsh L, Hallberg A, Welsh N, Betsholtz C, Arkhammar P, Nilsson T, Heldin CH, Berggren PO. Proc Natl Acad Sci U S A. 1990 Aug; 87(15):5807-11.
Review Structural and functional aspects of platelet-derived growth factor and its receptors. [Ciba Found Symp. 1990]
Review Structural and functional aspects of platelet-derived growth factor and its receptors.
Westermark B, Claesson-Welsh L, Heldin CH. Ciba Found Symp. 1990; 150:6-14; discussion 14-22.
Review Structural and functional aspects of the receptors for platelet-derived growth factor. [Prog Growth Factor Res. 1989]
Review Structural and functional aspects of the receptors for platelet-derived growth factor.
Westermark B, Claesson-Welsh L, Heldin CH. Prog Growth Factor Res. 1989; 1(4):253-66.

See reviews... See all...

Cited by 26 PubMed Central articles

Cognitive and socio-emotional deficits in platelet-derived growth factor receptor-β gene knockout mice. [PLoS One. 2011]
Cognitive and socio-emotional deficits in platelet-derived growth factor receptor-β gene knockout mice.
Nguyen PT, Nakamura T, Hori E, Urakawa S, Uwano T, Zhao J, Li R, Bac ND, Hamashima T, Ishii Y, et al. PLoS One. 2011 Mar 18; 6(3):e18004. Epub 2011 Mar 18.
Pericyte-specific expression of PDGF beta receptor in mouse models with normal and deficient PDGF beta receptor signaling. [Mol Neurodegener. 2010]
Pericyte-specific expression of PDGF beta receptor in mouse models with normal and deficient PDGF beta receptor signaling.
Winkler EA, Bell RD, Zlokovic BV. Mol Neurodegener. 2010 Aug 25; 5:32. Epub 2010 Aug 25.
Platelet-derived growth factor-mediated induction of the synaptic plasticity gene Arc/Arg3.1. [J Biol Chem. 2010]
Platelet-derived growth factor-mediated induction of the synaptic plasticity gene Arc/Arg3.1.
Peng F, Yao H, Bai X, Zhu X, Reiner BC, Beazely M, Funa K, Xiong H, Buch S. J Biol Chem. 2010 Jul 9; 285(28):21615-24. Epub 2010 May 7.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Neurotrophic activity of platelet-derived growth factor (PDGF): Rat neuronal cel...
Neurotrophic activity of platelet-derived growth factor (PDGF): Rat neuronal cells possess functional PDGF beta-type receptors and respond to PDGF.
Proc Natl Acad Sci U S A. 1991 Sep 15 ;88(18):8159-63.

PubMed
A specific amyloid-beta protein assembly in the brain impairs memory.
A specific amyloid-beta protein assembly in the brain impairs memory.
Nature. 2006 Mar 16 ;440(7082):352-7.

PubMed
Memory and the hippocampus: a synthesis from findings with rats, monkeys, and hu...
Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans.
Psychol Rev. 1992 Apr ;99(2):195-231.

PubMed
Molecular interactions of the IGF system.
Molecular interactions of the IGF system.
Cytokine Growth Factor Rev. 2005 Aug-Oct ;16(4-5):421-39.

PubMed
Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene t...
Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells.
Proc Natl Acad Sci U S A. 1992 May 15 ;89(10):4471-5.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: