Exp Cell Res. 1991 Sep;196(1):33-9.

A role for both RB and p53 in the regulation of human cellular senescence.

Source

Department of Cell Biology and Neuroscience, University of Texas, Southwestern Medical Center, Dallas 75235.

Abstract

We present evidence for the possible involvement of both the RB and p53 proteins in the regulation of cellular senescence. Human fibroblasts immortalized with an inducible SV40 T-antigen become senescent following the de-induction of T-antigen. Plasmids expressing an alternative source of intact T-antigen restore proliferation but T-antigen deletion mutants lacking either the RB or p53 binding domains are unable to do so. Similarly, combinations of adenovirus E1A + E1B or human papillomavirus E6 + E7 genes are able to replace T-antigen functions and permit cell proliferation, whereas the individual genes do not. These results are discussed in terms of a two-stage model for the escape from in vitro cellular senescence.

PMID:: 1652450; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Supplemental Content

Save items

Related citations in PubMed

Molecular analysis of H2O2-induced senescent-like growth arrest in normal human fibroblasts: p53 and Rb control G1 arrest but not cell replication. [Biochem J. 1998]
Molecular analysis of H2O2-induced senescent-like growth arrest in normal human fibroblasts: p53 and Rb control G1 arrest but not cell replication.
Chen QM, Bartholomew JC, Campisi J, Acosta M, Reagan JD, Ames BN. Biochem J. 1998 May 15; 332 ( Pt 1):43-50.
Effect of BPV1 E2-mediated inhibition of E6/E7 expression in HPV16-positive cervical carcinoma cells. [Gynecol Oncol. 2001]
Effect of BPV1 E2-mediated inhibition of E6/E7 expression in HPV16-positive cervical carcinoma cells.
Moon MS, Lee CJ, Um SJ, Park JS, Yang JM, Hwang ES. Gynecol Oncol. 2001 Feb; 80(2):168-75.
DNA tumor virus oncoproteins and retinoblastoma gene mutations share the ability to relieve the cell's requirement for cyclin D1 function in G1. [J Cell Biol. 1994]
DNA tumor virus oncoproteins and retinoblastoma gene mutations share the ability to relieve the cell's requirement for cyclin D1 function in G1.
Lukas J, Müller H, Bartkova J, Spitkovsky D, Kjerulff AA, Jansen-Dürr P, Strauss M, Bartek J. J Cell Biol. 1994 May; 125(3):625-38.
Review The p53 tumor suppressor gene and gene product. [Princess Takamatsu Symp. 1989]
Review The p53 tumor suppressor gene and gene product.
Levine AJ. Princess Takamatsu Symp. 1989; 20:221-30.
Review Biological activities and molecular targets of the human papillomavirus E7 oncoprotein. [Oncogene. 2001]
Review Biological activities and molecular targets of the human papillomavirus E7 oncoprotein.
Münger K, Basile JR, Duensing S, Eichten A, Gonzalez SL, Grace M, Zacny VL. Oncogene. 2001 Nov 26; 20(54):7888-98.

See reviews... See all...

Cited by 82 PubMed Central articles

Cellular Senescence - its role in cancer and the response to ionizing radiation. [Genome Integr. 2011]
Cellular Senescence - its role in cancer and the response to ionizing radiation.
Sabin RJ, Anderson RM. Genome Integr. 2011 Aug 11; 2(1):7. Epub 2011 Aug 11.
Review How does genome instability affect lifespan?: roles of rDNA and telomeres. [Genes Cells. 2011]
Review How does genome instability affect lifespan?: roles of rDNA and telomeres.
Kobayashi T. Genes Cells. 2011 Jun; 16(6):617-24.
Regulation of senescence in cancer and aging. [J Aging Res. 2011]
Regulation of senescence in cancer and aging.
Kong Y, Cui H, Ramkumar C, Zhang H. J Aging Res. 2011 Mar 8; 2011:963172. Epub 2011 Mar 8.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

A role for both RB and p53 in the regulation of human cellular senescence.
A role for both RB and p53 in the regulation of human cellular senescence.
Exp Cell Res. 1991 Sep ;196(1):33-9.

PubMed
Changes in chromatin structure and mobility in living cells at sites of DNA doub...
Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks.
J Cell Biol. 2006 Mar 13 ;172(6):823-34. Epub 2006 Mar 6 .

PubMed
The structure and evolution of subtelomeric Y' repeats in Saccharomyces cerevisi...
The structure and evolution of subtelomeric Y' repeats in Saccharomyces cerevisiae.
Genetics. 1992 Jul ;131(3):559-74.

PubMed
Critical role of the ubiquitin ligase activity of UHRF1, a nuclear RING finger p...
Critical role of the ubiquitin ligase activity of UHRF1, a nuclear RING finger protein, in tumor cell growth.
Mol Biol Cell. 2005 Dec ;16(12):5621-9. Epub 2005 Sep 29 .

PubMed
Evidence that MutY and MutM combine to prevent mutations by an oxidatively damag...
Evidence that MutY and MutM combine to prevent mutations by an oxidatively damaged form of guanine in DNA.
Proc Natl Acad Sci U S A. 1992 Aug 1 ;89(15):7022-5.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

A role for both RB and p53 in the regulation of human cellular senescence.

Source

Abstract

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Libraries

Supplemental Content

Save items

Related citations in PubMed

Cited by 82 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information