Immunol Today. 1991 Mar;12(3):A49-53.

The role of IL-10 in crossregulation of TH1 and TH2 responses.

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Dept of Immunology, University of Alberta, Edmonton, Canada.

Abstract

The identification of helper T (TH)-cell subsets has greatly improved understanding of the regulation of immune effector functions. In addition to controlling humoral and delayed-type hypersensitivity responses, these subsets crossregulate by secreting mutually inhibitory cytokines. In this review, Tim Mosmann and Kevin Moore examine these phenomena and in particular the role of interleukin 10, a cytokine secreted by TH2 cells that inhibits TH1-cell function.

PMID:: 1648926; [PubMed - indexed for MEDLINE]

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