Nature. 1991 Jun 13;351(6327):535-41.

Multiple intercellular signalling systems control the development of the Caenorhabditis elegans vulva.

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Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge 02139.

Abstract

Developmental, genetic and molecular studies indicate that multiple intercellular signalling systems interact to specify the types and spatial patterns of cells generated during the formation of the vulva of the nematode Caenorhabditis elegans. Two classes of evolutionarily conserved transmembrane receptors and a Ras protein function in these signalling systems. The biology of vulval development provides a framework for understanding how cell interactions control the development of animals as diverse as nematodes, insects and mammals.

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Review Signal transduction during C. elegans vulval induction. [Trends Genet. 1991]
Review Signal transduction during C. elegans vulval induction.
Sternberg PW, Horvitz HR. Trends Genet. 1991 Nov-Dec; 7(11-12):366-71.
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