FEBS Lett. 1992 Jul 28;307(2):131-4.

The WD-40 repeat.

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Division of Cellular Biochemistry, Netherlands Cancer Institute, Amsterdam.

Abstract

An amino acid sequence motif, called the WD-40 repeat, has been found as a repeat in a large variety of proteins that do not share any obvious functional properties. At present, the function of the repeated motif is not known for any of these proteins. Interestingly, recent experiments in yeast indicate that several proteins containing the WD-40 repeat are genetically associated with members of the TPR-family, a protein family that is characterized by the presence of another repeated motif of unknown function: the tetratricopeptide repeat. It is conceivable that proteins containing the WD-40 repeat interact physically with members of the TPR-family via their respective repeated motifs.

PMID:: 1644165; [PubMed - indexed for MEDLINE]

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Folding of proteins with WD-repeats: comparison of six members of the WD-repeat superfamily to the G protein beta subunit. [Biochemistry. 1996]
Folding of proteins with WD-repeats: comparison of six members of the WD-repeat superfamily to the G protein beta subunit.
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Cited by 56 PubMed Central articles

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Genomic survey, expression profile and co-expression network analysis of OsWD40 family in rice.
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Zhu HL, Wei X, Qu SL, Zhang C, Zuo XX, Feng YS, Luo Q, Chen GW, Liu MD, Jiang L, et al. Exp Mol Med. 2011 Aug 31; 43(8):437-45.
WD40 repeat propellers define a ubiquitin-binding domain that regulates turnover of F box proteins. [Mol Cell. 2010]
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