Curr Top Microbiol Immunol. 2005;296:1-17.

Molecular mimicry, microbial infection, and autoimmune disease: evolution of the concept.

Source

Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA. mbaobo@scripps.edu

Abstract

Molecular mimicry is defined as similar structures shared by molecules from dissimilar genes or by their protein products. Either several linear amino acids or their conformational fit may be shared, even though their origins are separate. Hence, during a viral or microbe infection, if that organism shares cross-reactive epitopes for B or T cells with the host, then the response to the infecting agent will also attack the host, causing autoimmune disease. A variation on this theme is when a second, third, or repeated infection(s) shares cross-reactive B or T cell epitopes with the first (initiating) virus but not necessarily the host. In this instance, the secondary infectious agents increase the number of antiviral/antihost effector antibodies or T cells that potentiate or precipitate the autoimmune assault. The formation of this concept initially via study of monoclonal antibody or clone T cell cross-recognition in vitro through its evolution to in vivo animal models and to selected human diseases is explored in this mini-review.

PMID:: 16329189; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Supplemental Content

Save items

Related citations in PubMed

Review [Molecular mimicry and mechanisms of autoantibody production]. [Nihon Rinsho. 1997]
Review [Molecular mimicry and mechanisms of autoantibody production].
Miyazawa M. Nihon Rinsho. 1997 Jun; 55(6):1370-6.
Review Molecular mimicry and immune-mediated diseases. [FASEB J. 1998]
Review Molecular mimicry and immune-mediated diseases.
Oldstone MB. FASEB J. 1998 Oct; 12(13):1255-65.
Review Molecular mimicry: can epitope mimicry induce autoimmune disease? [Immunol Cell Biol. 1997]
Review Molecular mimicry: can epitope mimicry induce autoimmune disease?
Davies JM. Immunol Cell Biol. 1997 Apr; 75(2):113-26.
Review Molecular and cellular mechanisms, pathogenesis, and treatment of insulin-dependent diabetes obtained through study of a transgenic model of molecular mimicry. [Curr Top Microbiol Immunol. 2005]
Review Molecular and cellular mechanisms, pathogenesis, and treatment of insulin-dependent diabetes obtained through study of a transgenic model of molecular mimicry.
Oldstone MB. Curr Top Microbiol Immunol. 2005; 296:65-87.
Identification of candidate T-cell epitopes and molecular mimics in chronic Lyme disease. [Nat Med. 1999]
Identification of candidate T-cell epitopes and molecular mimics in chronic Lyme disease.
Hemmer B, Gran B, Zhao Y, Marques A, Pascal J, Tzou A, Kondo T, Cortese I, Bielekova B, Straus SE, et al. Nat Med. 1999 Dec; 5(12):1375-82.

See reviews... See all...

Cited by 13 PubMed Central articles

Diversity in autoimmunity against retinal, neuronal, and axonal antigens in acquired neuro-retinopathy. [J Ophthalmic Inflamm Infect. 2...]
Diversity in autoimmunity against retinal, neuronal, and axonal antigens in acquired neuro-retinopathy.
Adamus G, Brown L, Schiffman J, Iannaccone A. J Ophthalmic Inflamm Infect. 2011 Sep; 1(3):111-21. Epub 2011 Jul 10.
Association of Mycobacterium avium subsp. paratuberculosis with multiple sclerosis in Sardinian patients. [PLoS One. 2011]
Association of Mycobacterium avium subsp. paratuberculosis with multiple sclerosis in Sardinian patients.
Cossu D, Cocco E, Paccagnini D, Masala S, Ahmed N, Frau J, Marrosu MG, Sechi LA. PLoS One. 2011 Apr 13; 6(4):e18482. Epub 2011 Apr 13.
The HLA class II Allele DRB1*1501 is over-represented in patients with idiopathic pulmonary fibrosis. [PLoS One. 2011]
The HLA class II Allele DRB1*1501 is over-represented in patients with idiopathic pulmonary fibrosis.
Xue J, Gochuico BR, Alawad AS, Feghali-Bostwick CA, Noth I, Nathan SD, Rosen GD, Rosas IO, Dacic S, Ocak I, et al. PLoS One. 2011 Feb 23; 6(2):e14715. Epub 2011 Feb 23.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Molecular mimicry, microbial infection, and autoimmune disease: evolution of the...
Molecular mimicry, microbial infection, and autoimmune disease: evolution of the concept.
Curr Top Microbiol Immunol. 2005 ;296:1-17.

PubMed
Occupational asthma in a beet sugar processing plant.
Occupational asthma in a beet sugar processing plant.
Chest. 1992 Jun ;101(6):1720-2.

PubMed
Lysis with Saponin improves detection of the response through CD203c and CD63 in...
Lysis with Saponin improves detection of the response through CD203c and CD63 in the basophil activation test after crosslinking of the high affinity IgE receptor FcepsilonRI.
Clin Mol Allergy. 2005 Jul 4 ;3:10.

PubMed
Chronic granulomatous disease presenting with osteomyelitis: favorable response ...
Chronic granulomatous disease presenting with osteomyelitis: favorable response to treatment with interferon-gamma.
J Pediatr Orthop. 1992 May-Jun ;12(3):398-400.

PubMed
Mold sensitization is common amongst patients with severe asthma requiring multi...
Mold sensitization is common amongst patients with severe asthma requiring multiple hospital admissions.
BMC Pulm Med. 2005 Feb 18 ;5:4.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Molecular mimicry, microbial infection, and autoimmune disease: evolution of the concept.

Source

Abstract

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Other Literature Sources

Medical

Libraries

Supplemental Content

Save items

Related citations in PubMed

Cited by 13 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information