Pathol Res Pract. 2005;201(11):713-25. Epub 2005 Oct 3.

The molecular genetics of breast cancer: the contribution of comparative genomic hybridization.

Reis-Filho JS, Simpson PT, Gale T, Lakhani SR.

Source

The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London, UK. jorgerf@icr.ac.uk

Abstract

Comparative genomic hybridization (CGH) has been the technique of choice over the last 10 years for mapping DNA copy number changes in human tumors. Here we review the literature to demonstrate how CGH has contributed to the comprehension of molecular aspects of breast tumorigenesis. At least two distinct molecular pathways of breast cancer have been characterized that show a strong correlation with histological grade. It seems that grade I invasive ductal carcinomas (IDCs) arise from well-differentiated ductal carcinoma in situ (DCIS), whereas grade III IDCs come from poorly differentiated DCIS. In addition, dedifferentiation from a low- to a high-grade breast cancer has proven an unlikely phenomenon. CGH has been instrumental in dissecting distinct molecular pathways toward breast malignancy and in establishing a direct relationship between genotype and clinical pathological features.

PMID:: 16325514; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Supplemental Content

Save items

Related citations in PubMed

Genetic changes in intraductal breast cancer detected by comparative genomic hybridization. [Am J Pathol. 1997]
Genetic changes in intraductal breast cancer detected by comparative genomic hybridization.
Kuukasjärvi T, Tanner M, Pennanen S, Karhu R, Kallioniemi OP, Isola J. Am J Pathol. 1997 Apr; 150(4):1465-71.
Ductal epithelial proliferations of the breast: a biological continuum? Comparative genomic hybridization and high-molecular-weight cytokeratin expression patterns. [J Pathol. 2001]
Ductal epithelial proliferations of the breast: a biological continuum? Comparative genomic hybridization and high-molecular-weight cytokeratin expression patterns.
Boecker W, Buerger H, Schmitz K, Ellis IA, van Diest PJ, Sinn HP, Geradts J, Diallo R, Poremba C, Herbst H. J Pathol. 2001 Nov; 195(4):415-21.
Comparative genomic hybridization of ductal carcinoma in situ of the breast-evidence of multiple genetic pathways. [J Pathol. 1999]
Comparative genomic hybridization of ductal carcinoma in situ of the breast-evidence of multiple genetic pathways.
Buerger H, Otterbach F, Simon R, Poremba C, Diallo R, Decker T, Riethdorf L, Brinkschmidt C, Dockhorn-Dworniczak B, Boecker W. J Pathol. 1999 Mar; 187(4):396-402.
Review Molecular evolution of breast cancer. [J Pathol. 2005]
Review Molecular evolution of breast cancer.
Simpson PT, Reis-Filho JS, Gale T, Lakhani SR. J Pathol. 2005 Jan; 205(2):248-54.
Review The diagnosis and management of pre-invasive breast disease: genetic alterations in pre-invasive lesions. [Breast Cancer Res. 2003]
Review The diagnosis and management of pre-invasive breast disease: genetic alterations in pre-invasive lesions.
Reis-Filho JS, Lakhani SR. Breast Cancer Res. 2003; 5(6):313-9. Epub 2003 Oct 9.

See reviews... See all...

Cited by 5 PubMed Central articles

Early Breast Cancer Precursor Lesions: Lessons Learned from Molecular and Clinical Studies. [Breast Care (Basel). 2010]
Early Breast Cancer Precursor Lesions: Lessons Learned from Molecular and Clinical Studies.
Sinn HP, Elsawaf Z, Helmchen B, Aulmann S. Breast Care (Basel). 2010 Aug; 5(4):218-226. Epub 2010 Aug 23.
Altered Endoplasmic Reticulum Calcium Pump Expression during Breast Tumorigenesis. [Breast Cancer (Auckl). 2011]
Altered Endoplasmic Reticulum Calcium Pump Expression during Breast Tumorigenesis.
Papp B, Brouland JP. Breast Cancer (Auckl). 2011; 5:163-74. Epub 2011 Jul 14.
High and intermediate grade ductal carcinoma in-situ of the breast: a comparison of pathologic features in core biopsies and excisions and an evaluation of core biopsy features that may predict a close or positive margin in the excision. [Diagn Pathol. 2009]
High and intermediate grade ductal carcinoma in-situ of the breast: a comparison of pathologic features in core biopsies and excisions and an evaluation of core biopsy features that may predict a close or positive margin in the excision.
Fadare O, Clement NF, Ghofrani M. Diagn Pathol. 2009 Aug 19; 4:26. Epub 2009 Aug 19.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

The molecular genetics of breast cancer: the contribution of comparative genomic...
The molecular genetics of breast cancer: the contribution of comparative genomic hybridization.
Pathol Res Pract. 2005 ;201(11):713-25. Epub 2005 Oct 3 .

PubMed
Unlimited division potential of precancerous mouse mammary cells after spontaneo...
Unlimited division potential of precancerous mouse mammary cells after spontaneous or carcinogen-induced transformation.
Fed Proc. 1975 Jan ;34(1):64-7.

PubMed
Chemical blockage of the proteasome inhibitory function of bortezomib: impact on...
Chemical blockage of the proteasome inhibitory function of bortezomib: impact on tumor cell death.
J Biol Chem. 2006 Jan 13 ;281(2):1107-18. Epub 2005 Nov 8 .

PubMed
Epidermal growth factor receptor and other oncogenes as prognostic markers.
Epidermal growth factor receptor and other oncogenes as prognostic markers.
J Natl Cancer Inst Monogr. 1992 ;(11):181-7.

PubMed
Clinical significance of estrogen receptor beta in breast cancer.
Clinical significance of estrogen receptor beta in breast cancer.
Cancer Chemother Pharmacol. 2005 Nov ;56 Suppl 1:21-6.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

The molecular genetics of breast cancer: the contribution of comparative genomic hybridization.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Libraries

Supplemental Content

Save items

Related citations in PubMed

Cited by 5 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information