Science. 2005 Nov 25;310(5752):1340-3.

Nucleus accumbens long-term depression and the expression of behavioral sensitization.

Brebner K, Wong TP, Liu L, Liu Y, Campsall P, Gray S, Phelps L, Phillips AG, Wang YT.

Source

Brain Research Centre, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada.

Abstract

Drug-dependent neural plasticity related to drug addiction and schizophrenia can be modeled in animals as behavioral sensitization, which is induced by repeated noncontingent or self-administration of many drugs of abuse. Molecular mechanisms that are critical for behavioral sensitization have yet to be specified. Long-term depression (LTD) of alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid receptor (AMPAR)-mediated synaptic transmission in the brain has been proposed as a cellular substrate for learning and memory. The expression of LTD in the nucleus accumbens (NAc) required clathrin-dependent endocytosis of postsynaptic AMPARs. NAc LTD was blocked by a dynamin-derived peptide that inhibited clathrin-mediated endocytosis or by a GluR2-derived peptide that blocked regulated AMPAR endocytosis. Systemic or intra-NAc infusion of the membrane-permeable GluR2 peptide prevented the expression of amphetamine-induced behavioral sensitization in the rat.

PMID:: 16311338; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Research Support, Non-U.S. Gov't

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Molecular Biology Databases

DEXTROAMPHETAMINE - HSDB

Libraries

LinkOut Holdings

Supplemental Content

Save items

Related citations in PubMed

Long-term depression in the nucleus accumbens: a neural correlate of behavioral sensitization to cocaine. [Nat Neurosci. 2001]
Long-term depression in the nucleus accumbens: a neural correlate of behavioral sensitization to cocaine.
Thomas MJ, Beurrier C, Bonci A, Malenka RC. Nat Neurosci. 2001 Dec; 4(12):1217-23.
Review Probing the role of AMPAR endocytosis and long-term depression in behavioural sensitization: relevance to treatment of brain disorders, including drug addiction. [Br J Pharmacol. 2008]
Review Probing the role of AMPAR endocytosis and long-term depression in behavioural sensitization: relevance to treatment of brain disorders, including drug addiction.
Wang YT. Br J Pharmacol. 2008 Mar; 153 Suppl 1:S389-95. Epub 2007 Dec 3.
Dopamine D3 receptors regulate GABAA receptor function through a phospho-dependent endocytosis mechanism in nucleus accumbens. [J Neurosci. 2006]
Dopamine D3 receptors regulate GABAA receptor function through a phospho-dependent endocytosis mechanism in nucleus accumbens.
Chen G, Kittler JT, Moss SJ, Yan Z. J Neurosci. 2006 Mar 1; 26(9):2513-21.
Regulation of AMPA receptor-mediated synaptic transmission by clathrin-dependent receptor internalization. [Neuron. 2000]
Regulation of AMPA receptor-mediated synaptic transmission by clathrin-dependent receptor internalization.
Man HY, Lin JW, Ju WH, Ahmadian G, Liu L, Becker LE, Sheng M, Wang YT. Neuron. 2000 Mar; 25(3):649-62.
Review AMPA receptor plasticity in the nucleus accumbens after repeated exposure to cocaine. [Neurosci Biobehav Rev. 2010]
Review AMPA receptor plasticity in the nucleus accumbens after repeated exposure to cocaine.
Wolf ME, Ferrario CR. Neurosci Biobehav Rev. 2010 Nov; 35(2):185-211. Epub 2010 Jan 28.

See reviews... See all...

Cited by 37 PubMed Central articles

The regulatory role of long-term depression in juvenile and adult mouse ocular dominance plasticity. [Sci Rep. 2011]
The regulatory role of long-term depression in juvenile and adult mouse ocular dominance plasticity.
Yang K, Xiong W, Yang G, Kojic L, Wang YT, Cynader M. Sci Rep. 2011; 1:203. Epub 2011 Dec 21.
Inhibition of PKMzeta in nucleus accumbens core abolishes long-term drug reward memory. [J Neurosci. 2011]
Inhibition of PKMzeta in nucleus accumbens core abolishes long-term drug reward memory.
Li YQ, Xue YX, He YY, Li FQ, Xue LF, Xu CM, Sacktor TC, Shaham Y, Lu L. J Neurosci. 2011 Apr 6; 31(14):5436-46.
Synaptic neurotransmission depression in ventral tegmental dopamine neurons and cannabinoid-associated addictive learning. [PLoS One. 2010]
Synaptic neurotransmission depression in ventral tegmental dopamine neurons and cannabinoid-associated addictive learning.
Liu Z, Han J, Jia L, Maillet JC, Bai G, Xu L, Jia Z, Zheng Q, Zhang W, Monette R, et al. PLoS One. 2010 Dec 20; 5(12):e15634. Epub 2010 Dec 20.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Nucleus accumbens long-term depression and the expression of behavioral sensitiz...
Nucleus accumbens long-term depression and the expression of behavioral sensitization.
Science. 2005 Nov 25 ;310(5752):1340-3.

PubMed
Parametric sequence comparisons.
Parametric sequence comparisons.
Proc Natl Acad Sci U S A. 1992 Jul 1 ;89(13):6090-3.

PubMed
A plastid in the making: evidence for a second primary endosymbiosis.
A plastid in the making: evidence for a second primary endosymbiosis.
Protist. 2005 Dec ;156(4):425-32. Epub 2005 Oct 12 .

PubMed
Whole genome amplification from a single cell: implications for genetic analysis...
Whole genome amplification from a single cell: implications for genetic analysis.
Proc Natl Acad Sci U S A. 1992 Jul 1 ;89(13):5847-51.

PubMed
Patient reports of symptoms and their treatment at three palliative care project...
Patient reports of symptoms and their treatment at three palliative care projects servicing individuals with HIV/AIDS.
J Pain Symptom Manage. 2005 Nov ;30(5):408-17.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: