Proc Natl Acad Sci U S A. 1992 Jul 1;89(13):6006-9.

Folate receptor allows cells to grow in low concentrations of 5-methyltetrahydrofolate.

Matsue H, Rothberg KG, Takashima A, Kamen BA, Anderson RG, Lacey SW.

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Department of Dermatology, University of Texas Southwestern Medical Center, Dallas 75235-9039.

Abstract

The folate receptor mediates the uptake of 5-methyltetrahydrofolate in certain cultured cells by a process called potocytosis. When these cells are grown in physiological concentrations of folate, the receptor increases the efficiency of vitamin uptake by 30-fold. We now show that PAM 212 cells, a mouse keratinocyte cell line, are unable to grow in 1 nM 5-methyltetrahydrofolate unless they express a functional folate receptor. These results suggest that under certain conditions, tissue cells in the body may depend on the folate receptor to obtain enough 5-methyltetrahydrofolate for growth.

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