Nature. 2005 Nov 24;438(7067):449-53.

Foundations for engineering biology.

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Division of Biological Engineering, Massachusetts Institute of Technology, Room 68-580, Koch Biology Building, 31 Ames Street, Cambridge, Massachusetts 02139, USA. endy@mit.edu

Abstract

Engineered biological systems have been used to manipulate information, construct materials, process chemicals, produce energy, provide food, and help maintain or enhance human health and our environment. Unfortunately, our ability to quickly and reliably engineer biological systems that behave as expected remains quite limited. Foundational technologies that make routine the engineering of biology are needed. Vibrant, open research communities and strategic leadership are necessary to ensure that the development and application of biological technologies remains overwhelmingly constructive.

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