Mol Biol Evol. 1992 Jul;9(4):678-87.

Estimation of the number of nucleotide substitutions when there are strong transition-transversion and G+C-content biases.

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Department of Biology, Tokyo Metropolitan University.

Abstract

A simple mathematical method is developed to estimate the number of nucleotide substitutions per site between two DNA sequences, by extending Kimura's (1980) two-parameter method to the case where a G+C-content bias exists. This method will be useful when there are strong transition-transversion and G+C-content biases, as in the case of Drosophila mitochondrial DNA.

PMID:: 1630306; [PubMed - indexed for MEDLINE]

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Estimation of the number of nucleotide substitutions when there are strong transition-transversion and G+C-content biases.

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