Microbes Infect. 2006 Feb;8(2):487-92. Epub 2005 Oct 3.

Gastrointestinal nematode infection is associated with variation in innate immune responsiveness.

Jackson JA, Turner JD, Kamal M, Wright V, Bickle Q, Else KJ, Ramsan M, Bradley JE.

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School of Biology, Nottingham University, Nottingham, UK.

Abstract

Ex vivo monocyte cytokine responses (IL-1beta, TNF-alpha, IL-12p70, IL-10, TGF-beta) to bacterial TLR2 and TLR4 ligands were quantified in 47 gastrointestinal (GI) nematode-exposed children in Pemba Island, Tanzania. Worminess (estimated by faecal egg counts (FEC)) had a positive relationship with pro-inflammatory TNF-alpha and IL-1beta responsiveness to the TLR ligands. In particular, there was a strong significant relationship with TNF-alpha response to TLR4 ligand (LPS). There were no significant associations between regulatory responses (IL-10, TGF-beta) and worminess. These results are consistent with the possibility that GI nematodes modulate innate responses and may indicate a potential mechanism for interactions between GI nematodiasis and important bystander pathogens.

PMID:: 16293435; [PubMed - indexed for MEDLINE]

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