Clin Infect Dis. 2005 Dec 15;41(12):1817-9. Epub 2005 Nov 8.

A polymorphism of intercellular adhesion molecule-1 is associated with a reduced incidence of nonmalarial febrile illness in Kenyan children.

Jenkins NE, Mwangi TW, Kortok M, Marsh K, Craig AG, Williams TN.

Source

Kenya Medical Research Institute/Wellcome Trust Programme, Centre for Geographic Medicine Research, Kilifi, Kenya. njenkins@liverpool.ac.uk

Abstract

An intercellular adhesion molecule-1 polymorphism (ICAM-1(Kilifi)) is present at a high frequency across sub-Saharan Africa, and its presence may increase susceptibility to cerebral malaria. Here, we report that, compared with children in whom wild-type intercellular adhesion molecule-1 is present, the incidence of nonmalarial fever is significantly lower among those homozygous for ICAM-1(Kilifi). We propose that ICAM-1(Kilifi) may be associated with reduced rates of tissue damage and of death due to sepsis.

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PMCID:: PMC2727463

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Intercellular Adhesion Molecule-1

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