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    N Engl J Med. 1975 Jan 9;292(2):63-6.

    Parthenogenic origin of benign ovarian teratomas.

    Linder D, McCaw BK, Hecht F.

    Abstract

    To determine the origin of benign cystic teratomas of the ovary, chromosome-banding studies were done on normal tissues and teratomas from five patients. The normal tissues were heterozygous (+/-) for 17 chromosome polymorphisms at or near the centromere, whereas the teratomas were uniformly homozygous (+/+ or -/-). These findings and those employing electrophoretic variants indicate that ovarian teratomas are parthenogenic tumors that arise from a single germ cell after the first meiotic division.

    PMID:
    162806
    [PubMed - indexed for MEDLINE]

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