Cell Biochem Funct. 2006 Jan-Feb;24(1):7-12.

Snake venom hyaluronidase: a therapeutic target.

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Department of Biochemistry, University of Mysore, Mysore--570 006, India. kemparaj@rediffmail.com

Abstract

The diffusion of toxins from the site of a bite into the circulation is essential for successful envenomation. Degradation of hyaluronic acid in the extracellular matrix (ECM) by venom hyaluronidase is a key factor in this diffusion. Hyaluronidase not only increases the potency of other toxins but also damages the local tissue. In spite of its important role, little attention has been paid to this enzyme. Hyaluronidase exists in various isoforms and generates a wide range of hyaluronic acid degradation products. This suggests that beyond its role as a spreading factor venom hyaluronidase deserves to be explored as a possible therapeutic target for inhibiting the systemic distribution of venom and also for minimizing local tissue destruction at the site of the bite.

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Cited by 4 PubMed Central articles

Purification and characterization of two new allergens from the venom of Vespa magnifica. [PLoS One. 2012]
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