Science. 1992 Jul 3;257(5066):88-91.

Increased osteoclast development after estrogen loss: mediation by interleukin-6.

Jilka RL, Hangoc G, Girasole G, Passeri G, Williams DC, Abrams JS, Boyce B, Broxmeyer H, Manolagas SC.

Source

Department of Veterans Affairs Medical Center, Indiana University School of Medicine, Indianapolis 46202.

Abstract

Osteoclasts, the cells that resorb bone, develop from hematopoietic precursors of the bone marrow under the control of factors produced in their microenvironment. The cytokine interleukin-6 can promote hematopoiesis and osteoclastogenesis. Interleukin-6 production by bone and marrow stromal cells is suppressed by 17 beta-estradiol in vitro. In mice, estrogen loss (ovariectomy) increased the number of colony-forming units for granulocytes and macrophages, enhanced osteoclast development in ex vivo cultures of marrow, and increased the number of osteoclasts in trabecular bone. These changes were prevented by 17 beta-estradiol or an antibody to interleukin-6. Thus, estrogen loss results in an interleukin-6-mediated stimulation of osteoclastogenesis, which suggests a mechanism for the increased bone resorption in postmenopausal osteoporosis.

PMID:: 1621100; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Supplemental Content

Save items

Related citations in PubMed

In vitro and ex vivo evidence that estrogens suppress increased bone resorption induced by ovariectomy or PTH stimulation through an effect on osteoclastogenesis. [J Bone Miner Res. 1995]
In vitro and ex vivo evidence that estrogens suppress increased bone resorption induced by ovariectomy or PTH stimulation through an effect on osteoclastogenesis.
Most W, Schot L, Ederveen A, van der Wee-Pals L, Papapoulos S, Löwik C. J Bone Miner Res. 1995 Oct; 10(10):1523-30.
Effect of ormeloxifene on ovariectomy-induced bone resorption, osteoclast differentiation and apoptosis and TGF beta-3 expression. [J Steroid Biochem Mol Biol. 2006]
Effect of ormeloxifene on ovariectomy-induced bone resorption, osteoclast differentiation and apoptosis and TGF beta-3 expression.
Narayana Murthy PS, Sengupta S, Sharma S, Singh MM. J Steroid Biochem Mol Biol. 2006 Aug; 100(4-5):117-28. Epub 2006 Jun 21.
Estradiol and raloxifene decrease the formation of multinucleate cells in human bone marrow cultures. [Eur Cytokine Netw. 2002]
Estradiol and raloxifene decrease the formation of multinucleate cells in human bone marrow cultures.
Ramalho AC, Couttet P, Baudoin C, Morieux C, Graulet AM, de Vernejoul MC, Cohen-Solal ME. Eur Cytokine Netw. 2002 Jan-Mar; 13(1):39-45.
Review Cellular and molecular effects of growth hormone and estrogen on human bone cells. [APMIS Suppl. 1997]
Review Cellular and molecular effects of growth hormone and estrogen on human bone cells.
Kassem M. APMIS Suppl. 1997; 71:1-30.
Review Modulation of osteoclast differentiation by local factors. [Bone. 1995]
Review Modulation of osteoclast differentiation by local factors.
Suda T, Udagawa N, Nakamura I, Miyaura C, Takahashi N. Bone. 1995 Aug; 17(2 Suppl):87S-91S.

See reviews... See all...

Cited by over 100 PubMed Central articles

The role of osteoprotegerin (OPG) and estrogen receptor (ER-α) gene polymorphisms in rheumatoid arthritis. [Clin Cases Miner Bone Metab. 2...]
The role of osteoprotegerin (OPG) and estrogen receptor (ER-α) gene polymorphisms in rheumatoid arthritis.
Masi L, Maddali Bongi S, Angotti C, Del Monte F, Carbonell Sala S, Basetti M, Amedei A, Falchetti A, Brandi ML. Clin Cases Miner Bone Metab. 2007 May; 4(2):156-60.
Review Vitamin D and bone health: potential mechanisms. [Nutrients. 2010]
Review Vitamin D and bone health: potential mechanisms.
Laird E, Ward M, McSorley E, Strain JJ, Wallace J. Nutrients. 2010 Jul; 2(7):693-724. Epub 2010 Jul 5.
The effect of both a thoracic trauma and a soft-tissue trauma on fracture healing in a rat model. [Acta Orthop. 2011]
The effect of both a thoracic trauma and a soft-tissue trauma on fracture healing in a rat model.
Claes L, Ignatius A, Lechner R, Gebhard F, Kraus M, Baumgärtel S, Recknagel S, Krischak GD. Acta Orthop. 2011 Apr; 82(2):223-7.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

Increased osteoclast development after estrogen loss: mediation by interleukin-6...
Increased osteoclast development after estrogen loss: mediation by interleukin-6.
Science. 1992 Jul 3 ;257(5066):88-91.

PubMed
Rheumatoid factors: good or bad for you?
Rheumatoid factors: good or bad for you?
Int Arch Allergy Immunol. 2005 Oct ;138(2):180-8. Epub 2005 Oct 4 .

PubMed
Inhibition of mouse alveolar macrophage production of tumor necrosis factor alph...
Inhibition of mouse alveolar macrophage production of tumor necrosis factor alpha by acute in vivo and in vitro exposure to tobacco smoke.
Respiration. 1992 ;59(2):77-80.

PubMed
Pain exacerbation as a major source of lost productive time in US workers with a...
Pain exacerbation as a major source of lost productive time in US workers with arthritis.
Arthritis Rheum. 2005 Oct 15 ;53(5):673-81.

PubMed
CNTF and LIF act on neuronal cells via shared signaling pathways that involve th...
CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130.
Cell. 1992 Jun 26 ;69(7):1121-32.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Increased osteoclast development after estrogen loss: mediation by interleukin-6.

Source

Abstract

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Molecular Biology Databases

Libraries

Supplemental Content

Save items

Related citations in PubMed

Cited by over 100 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information