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    Mol Cell Biol. 1992 Jul;12(7):3070-7.

    Transcriptional repression by a novel member of the bZIP family of transcription factors.

    Cowell IG, Skinner A, Hurst HC.

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    Gene Transcription Laboratory, Imperial Cancer Research Fund, Hammersmith Hospital, London, England.

    Abstract

    We describe here a novel member of the bZIP family of DNA-binding proteins, designated E4BP4, that displays an unusual DNA-binding specificity which overlaps that of the activating transcription factor family of factors. When expressed in a transient transfection assay with a suitable reporter plasmid, E4BP4 strongly repressed transcription in a DNA-binding-site-dependent manner. Examination of a series of deletion mutants revealed that sequences responsible for the repressing potential of E4BP4 lie within the carboxyl-terminal region of the protein. No similarity was found between this region and the repressing domains of other known eukaryotic transcriptional repressors.

    PMID:
    1620116
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC364521
    Free PMC Article

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