Clin Rheumatol. 2006 Feb;25(1):16-20. Epub 2005 Sep 15.

IL-17 increased the production of vascular endothelial growth factor in rheumatoid arthritis synoviocytes.

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Pusan National University Hospital Institutes, Busan, South Korea.

Abstract

Interleukin-17 (IL-17) is a proinflammatory cytokine that is expressed in the synovium T cells of rheumatoid arthritis (RA). This cytokine is implicated in the inflammation and destruction of the joint. However, the role of IL-17 on the production of vascular endothelial factor (VEGF) important to synovial proliferation has still not been identified. In this study, we investigated the effect on cultured rheumatoid fibroblast-like synoviocytes (FLS) of the IL-17 on the production and expression of VEGF, which play an important role in angiogenesis in rheumatoid synovium. IL-17 increased the production of VEGF dose dependently and the mRNA expression of VEGF. These results suggest that IL-17 might influence angiogenesis in RA by up-regulating the expression of VEGF in rheumatoid FLS.

PMID:: 16163444; [PubMed - indexed for MEDLINE]

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IL-17 increased the production of vascular endothelial growth factor in rheumatoid arthritis synoviocytes.

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