Gene Ther. 2005 Sep;12(18):1353-9.

Gene therapy progress and prospects: viral trafficking during infection.

Source

Department of Microbiology and Immunology, University of Illinois at Chicago, 835 S. Wolcott Rm. E-703, Chicago, IL 60612, USA.

Abstract

The intracellular steps involved in viral infection, namely cytoplasmic trafficking and nuclear import, are critical events in the viral life cycle that have lagged behind other areas of viral research. This review examines recent advances in our understanding of these steps for viruses commonly employed as viral gene delivery vectors. Steps governing the cytoplasmic trafficking and nuclear import of Herpes Simplex virus, Human Immunodeficiency virus and Adenovirus are reviewed in this article.

PMID:: 16151445; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

Viral Proteins

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Medical

Libraries

LinkOut Holdings

Supplemental Content

Save items

Related citations in PubMed

Review Progress and prospects: gene therapy for genetic diseases with helper-dependent adenoviral vectors. [Gene Ther. 2008]
Review Progress and prospects: gene therapy for genetic diseases with helper-dependent adenoviral vectors.
Brunetti-Pierri N, Ng P. Gene Ther. 2008 Apr; 15(8):553-60. Epub 2008 Feb 21.
Cre-loxP adenovirus-mediated foreign gene expression in skin-equivalent keratinocytes. [Br J Dermatol. 2005]
Cre-loxP adenovirus-mediated foreign gene expression in skin-equivalent keratinocytes.
Hanakawa Y, Shirakata Y, Nagai H, Yahata Y, Tokumaru S, Yamasaki K, Tohyama M, Sayama K, Hashimoto K. Br J Dermatol. 2005 Jun; 152(6):1391-2.
Increased virus replication in mammalian cells by blocking intracellular innate defense responses. [Gene Ther. 2008]
Increased virus replication in mammalian cells by blocking intracellular innate defense responses.
de Vries W, Haasnoot J, van der Velden J, van Montfort T, Zorgdrager F, Paxton W, Cornelissen M, van Kuppeveld F, de Haan P, Berkhout B. Gene Ther. 2008 Apr; 15(7):545-52. Epub 2008 Feb 14.
Review Treatment of peripheral sensorineural hearing loss: gene therapy. [Gene Ther. 2004]
Review Treatment of peripheral sensorineural hearing loss: gene therapy.
Duan M, Venail F, Spencer N, Mezzina M. Gene Ther. 2004 Oct; 11 Suppl 1:S51-6.
Review Regulated nucleocytoplasmic trafficking of viral gene products: a therapeutic target? [Biochim Biophys Acta. 2008]
Review Regulated nucleocytoplasmic trafficking of viral gene products: a therapeutic target?
Alvisi G, Rawlinson SM, Ghildyal R, Ripalti A, Jans DA. Biochim Biophys Acta. 2008 Jan; 1784(1):213-27. Epub 2007 Aug 31.

See reviews... See all...

Cited by 9 PubMed Central articles

Efficient Nonviral Gene Therapy Using Folate-Targeted Chitosan-DNA Nanoparticles In Vitro. [ISRN Pharm. 2012]
Efficient Nonviral Gene Therapy Using Folate-Targeted Chitosan-DNA Nanoparticles In Vitro.
Jreyssaty C, Shi Q, Wang H, Qiu X, Winnik FM, Zhang X, Dai K, Benderdour M, Fernandes JC. ISRN Pharm. 2012; 2012:369270. Epub 2012 Mar 7.
The salivary secretome of the tsetse fly Glossina pallidipes (Diptera: Glossinidae) infected by salivary gland hypertrophy virus. [PLoS Negl Trop Dis. 2011]
The salivary secretome of the tsetse fly Glossina pallidipes (Diptera: Glossinidae) infected by salivary gland hypertrophy virus.
Kariithi HM, Ince IA, Boeren S, Abd-Alla AM, Parker AG, Aksoy S, Vlak JM, Oers MM. PLoS Negl Trop Dis. 2011 Nov; 5(11):e1371. Epub 2011 Nov 22.
Analysis of the viral elements required in the nuclear import of HIV-1 DNA. [J Virol. 2010]
Analysis of the viral elements required in the nuclear import of HIV-1 DNA.
Rivière L, Darlix JL, Cimarelli A. J Virol. 2010 Jan; 84(2):729-39. Epub 2009 Nov 4.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Gene therapy progress and prospects: viral trafficking during infection.
Gene therapy progress and prospects: viral trafficking during infection.
Gene Ther. 2005 Sep ;12(18):1353-9.

PubMed
Infection of cynomolgus monkeys with a chimeric HIV-1/SIVmac virus that expresse...
Infection of cynomolgus monkeys with a chimeric HIV-1/SIVmac virus that expresses the HIV-1 envelope glycoproteins.
J Acquir Immune Defic Syndr. 1992 ;5(7):639-46.

PubMed
High-dose recombinant Canarypox vaccine expressing HIV-1 protein, in seronegativ...
High-dose recombinant Canarypox vaccine expressing HIV-1 protein, in seronegative human subjects.
J Infect Dis. 2005 Oct 1 ;192(7):1249-59. Epub 2005 Aug 31 .

PubMed
Interleukin 4 potently enhances murine macrophage mannose receptor activity: a m...
Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation.
J Exp Med. 1992 Jul 1 ;176(1):287-92.

PubMed
Nuclear targeting of protein phosphatase-1 by HIV-1 Tat protein.
Nuclear targeting of protein phosphatase-1 by HIV-1 Tat protein.
J Biol Chem. 2005 Oct 28 ;280(43):36364-71. Epub 2005 Aug 29 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: