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Genet Vaccines Ther. 2005 Aug 22;3:7.

A combined nucleocapsid vaccine induces vigorous SARS-CD8+ T-cell immune responses.

Azizi A, Aucoin S, Tadesse H, Frost R, Ghorbani M, Soare C, Naas T, Diaz-Mitoma F.

Source

Infectious Disease and Vaccine Research Centre, Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, K1H 8L1, Canada. aliazizi555@yahoo.ca

Abstract

Several studies have shown that cell-mediated immune responses play a crucial role in controlling viral replication. As such, a candidate SARS vaccine should elicit broad CD8+ T-cell immune responses. Several groups of mice were immunized alone or in combination with SARS-nucleocapsid immunogen. A high level of specific SARS-CD8+ T-cell response was demonstrated in mice that received DNA encoding the SARS-nucleocapsid, protein and XIAP as an adjuvant. We also observed that co-administration of a plasmid expressing nucleocapsid, recombinant protein and montanide/CpG induces high antibody titers in immunized mice. Moreover, this vaccine approach merits further investigation as a potential candidate vaccine against SARS.

PMID:: 16115319; [PubMed]
PMCID: PMC1249587

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