Trends Genet. 2005 Oct;21(10):553-8.

Multievidence microarray mining.

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Genomatix Software GmbH, Landsbergerstr. 6, D-80339 München, Germany.

Abstract

Microarray mining is a challenging task because of the superposition of several processes in the data. We believe that the combination of microarray data-based analyses (statistical significance analysis of gene expression) with array-independent analyses (literature-mining and promoter analysis) enables some of the problems of traditional array analysis to be overcome. As a proof-of-principle, we revisited publicly available microarray data derived from an experiment with platelet-derived growth factor (PDGF)-stimulated fibroblasts. Our strategy revealed results beyond the detection of the major metabolic pathway known to be linked to the PDGF response: we were able to identify the crosstalking regulatory networks underlying the metabolic pathway without using a priori knowledge about the experiment.

PMID:: 16098629; [PubMed - indexed for MEDLINE]

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