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    Phys Rev E Stat Nonlin Soft Matter Phys. 2005 Jul;72(1 Pt 1):011903. Epub 2005 Jul 5.

    Budding and domain shape transformations in mixed lipid films and bilayer membranes.

    Source

    Department of Chemical Engineering, Johns Hopkins University, Baltimore, Maryland 21218-2689, USA. harden@jhu.edu

    Abstract

    We study the stability and shapes of domains with spontaneous curvature in fluid films and membranes, embedded in a surrounding membrane with zero spontaneous curvature. These domains can result from the inclusion of an impurity in a fluid membrane or from phase separation within the membrane. We show that for small but finite line and surface tensions and for finite spontaneous curvatures, an equilibrium phase of protruding circular domains is obtained at low impurity concentrations. At higher concentrations, we predict a transition from circular domains, or caplets, to stripes. In both cases, we calculate the shapes of these domains within the Monge representation for the membrane shape. With increasing line tension, we show numerically that there is a budding transformation from stable protruding circular domains to spherical buds. We calculate the full phase diagram and demonstrate two triple points of, respectively, bud-flat-caplet and flat-stripe-caplet coexistence.

    PMID:
    16089997
    [PubMed - indexed for MEDLINE]

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