Nat Rev Mol Cell Biol. 2005 Aug;6(8):635-45.

Transcriptional regulation and transformation by Myc proteins.

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Institute for Molecular Biology and Tumour Research, University of Marburg, Emil-Mannkopff-Strasse 2, 35033 Marburg, Germany.

Abstract

Myc genes are key regulators of cell proliferation, and their deregulation contributes to the genesis of most human tumours. Recently, a wealth of data has shed new light on the biochemical functions of Myc proteins and on the mechanisms through which they function in cellular transformation.

PMID:: 16064138; [PubMed - indexed for MEDLINE]

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