C R Seances Soc Biol Fil. 1979;173(3):654-9.

[Incorporation of tritiated thymidine into testicular deoxyribonucleic acid of the rat. Effect of inhibin].

[Article in French]

Bologne R, Demoulin A, Hustin J, Verstraelen-Proyard J, Gysen P, Franchimont P.

Abstract

tritiated thymidine is incorporated into DNA of spermatogonia type B as proved by autohistoradiography when injected in vivo three hours before the sacrifice. Maximum binding and specific activity (labelled thymidine expressed in DPM per mg DNA) are obtained in pubertal rats aged 42 days and weighting 150 g. Inhibin preparation extracted from rete testis fluid (RTF3) specifically inhibits tritiated thymidine into testicular DNA. Thus, no modification of incorporation into hepatic DNA is observed and the preparation loses its inhibitory effect when denatured by heating and trypsin digestion. Tritiated thymidine incorporation into testicular DNA is poor in normal adult rats and in pubertal hypophysectomized animals, RTF3 does not modify the thymidine incorporation in both conditions. The reasons for this lack of effect are discussed. An experimental condition of spermatogonial regeneration is obtained by testicular irradiation. Inhibin preparation inhibits the regenerative DNA synthesis.

PMID:: 160281; [PubMed - indexed for MEDLINE]

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[Effects of inhibin on the in vitro synthesis of desoxyribonucleic acid in the rat testis]. [C R Seances Soc Biol Fil. 1980]
[Effects of inhibin on the in vitro synthesis of desoxyribonucleic acid in the rat testis].
Croze F, Gysen P, Demoulin A, Franchimont P. C R Seances Soc Biol Fil. 1980; 174(2):205-10.
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Krummen LA, Toppari J, Kim WH, Morelos BS, Ahmad N, Swerdloff RS, Ling N, Shimasaki S, Esch F, Bhasin S. Endocrinology. 1989 Sep; 125(3):1630-7.
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[Origin and sites of action of inhibin (author's transl)].
Demoulin A, Verstraelen-Proyard J, Bourguignon JP, Hustin J, Koulischer L, Bologne R, Franchimont P. Ann Endocrinol (Paris). 1980 Jul-Aug; 41(4):291-302.

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