Ann N Y Acad Sci. 2005 Jun;1050:1-9.

Posttranslational modifications of self-antigens.

Source

Section of Rheumatology, Yale University School of Medicine, P.O. Box 208031, New Haven, CT 06520-8031, USA. hester.doyle@yale.edu

Abstract

Although the immune system has developed mechanisms to distinguish "self" from "non-self," the presence of autoimmune diseases demonstrates that these mechanisms can be bypassed. The posttranslational modification of self-antigens is one way in which "new" antigens are created for which immune tolerance does not exist. We review some of the posttranslationally modified self-antigens associated with autoimmune diseases, how they arise, and how they break immune tolerance.

PMID:: 16014515; [PubMed - indexed for MEDLINE]

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Review

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Autoantigens

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