Genome Biol. 2005;6(6):221. Epub 2005 May 27.

Making sense of nonsense: the evolution of selenocysteine usage in proteins.

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Department of Molecular Genetics, Microbiology and Immunology, UMDNJ-Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA. paul.copeland@umdnj.edu

Abstract

A recent analysis of sequences derived from organisms in the Sargasso Sea has revealed a surprisingly different set of selenium-containing proteins than that previously found in sequenced genomes and suggests that selenocysteine utilization has been lost by many groups of organisms during evolution.

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PMCID: PMC1175963

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Chemical compound information

Selenocysteine

MW: 167.04 g/mol

MF: C₃H₆NO₂Se

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