J Rheumatol Suppl. 1992 Apr;33:70-4.

Juvenile rheumatoid arthritis and HLA: report of the Park City III workshop.

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Virginia Mason Research Center, Department of Pediatrics, University of Washington School of Medicine, Seattle.

Abstract

The workshop held during the Park City Meeting was directed toward developing a consensus about HLA associations in juvenile rheumatoid arthritis (JRA). Most agreement was achieved in pauciarticular JRA where the strongest associations were with the HLA-DRB1 alleles as is also the case in IgM rheumatoid factor positive polyarticular disease. In addition, HLA-DP associations are being identified although roles for linked genes are still possible. The critical nucleotides among HLA genes are not known; however, disease specific mutations have not been shown.

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