Science. 1992 May 22;256(5060):1210-3.

Less mortality but more relapses in experimental allergic encephalomyelitis in CD8-/- mice.

Koh DR, Fung-Leung WP, Ho A, Gray D, Acha-Orbea H, Mak TW.

Source

Department of Medical Biophysics, University of Toronto, Princess Margaret Hospital, Canada.

Abstract

Mice lacking in CD8 were generated from homologous recombination in embryonal stem cells at the CD8 locus and bred with the experimental allergic encephalomyelitis (EAE)-susceptible PL/JH-2u through four backcross generations to investigate the role of CD8+ T cells in this model of multiple sclerosis. The disease onset and susceptibility were similar to those of wild-type mice. However, the mutant mice had a milder acute EAE, reflected by fewer deaths, but more chronic EAE, reflected by a higher frequency of relapse. This suggests that CD8+ T lymphocytes may participate as both effectors and regulators in this animal model.

PMID:: 1589800; [PubMed - indexed for MEDLINE]

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