Trends Microbiol. 2005 May;13(5):236-42.

ppGpp: a global regulator in Escherichia coli.

Source

Department of Cell and Molecular Biology-Microbiology, Göteborg University, Box 462, 405 30 Göteborg, Sweden.

Abstract

The small nucleotide ppGpp acts as a global regulator of gene expression in bacteria. Proteomic analysis of cells lacking ppGpp has shown that this nucleotide might affect many more genes than previously anticipated. These findings and others suggest that ppGpp causes a redirection of transcription so that genes important for starvation survival and virulence are favoured at the expense of those required for growth and proliferation. In addition, new insights into the mechanism by which ppGpp affects gene expression have been achieved owing to in vitro studies of ppGpp function, complemented by structural studies of the ppGpp-RNA polymerase complex.

PMID:: 15866041; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Libraries

LinkOut Holdings

Supplemental Content

Save items

Related citations in PubMed

The guanosine tetraphosphate (ppGpp) alarmone, DksA and promoter affinity for RNA polymerase in regulation of sigma-dependent transcription. [Mol Microbiol. 2006]
The guanosine tetraphosphate (ppGpp) alarmone, DksA and promoter affinity for RNA polymerase in regulation of sigma-dependent transcription.
Bernardo LM, Johansson LU, Solera D, Skärfstad E, Shingler V. Mol Microbiol. 2006 May; 60(3):749-64.
Promoter-specific control of E. coli RNA polymerase by ppGpp and a general transcription factor. [Genes Dev. 2009]
Promoter-specific control of E. coli RNA polymerase by ppGpp and a general transcription factor.
Roberts JW. Genes Dev. 2009 Jan 15; 23(2):143-6.
Response of RNA polymerase to ppGpp: requirement for the omega subunit and relief of this requirement by DksA. [Genes Dev. 2005]
Response of RNA polymerase to ppGpp: requirement for the omega subunit and relief of this requirement by DksA.
Vrentas CE, Gaal T, Ross W, Ebright RH, Gourse RL. Genes Dev. 2005 Oct 1; 19(19):2378-87.
Review Transcriptional switching in Escherichia coli during stress and starvation by modulation of sigma activity. [FEMS Microbiol Rev. 2010]
Review Transcriptional switching in Escherichia coli during stress and starvation by modulation of sigma activity.
Sharma UK, Chatterji D. FEMS Microbiol Rev. 2010 Sep; 34(5):646-57. Epub 2010 Apr 14.
Review General pathway for turning on promoters transcribed by RNA polymerases containing alternative sigma factors. [J Bacteriol. 2006]
Review General pathway for turning on promoters transcribed by RNA polymerases containing alternative sigma factors.
Gourse RL, Ross W, Rutherford ST. J Bacteriol. 2006 Jul; 188(13):4589-91.

See reviews... See all...

Cited by 76 PubMed Central articles

Stringent response of Escherichia coli: revisiting the bibliome using literature mining. [Microb Inform Exp. 2011]
Stringent response of Escherichia coli: revisiting the bibliome using literature mining.
Carneiro S, Lourenço A, Ferreira EC, Rocha I. Microb Inform Exp. 2011 Dec 30; 1(1):14. Epub 2011 Dec 30.
The -omics Era- Toward a Systems-Level Understanding of Streptomyces. [Curr Genomics. 2011]
The -omics Era- Toward a Systems-Level Understanding of Streptomyces.
Zhou Z, Gu J, Du YL, Li YQ, Wang Y. Curr Genomics. 2011 Sep; 12(6):404-16.
Transcriptome profiling of a curdlan-producing Agrobacterium reveals conserved regulatory mechanisms of exopolysaccharide biosynthesis. [Microb Cell Fact. 2012]
Transcriptome profiling of a curdlan-producing Agrobacterium reveals conserved regulatory mechanisms of exopolysaccharide biosynthesis.
Ruffing AM, Chen RR. Microb Cell Fact. 2012 Feb 3; 11:17. Epub 2012 Feb 3.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
BioSystems
Pathways and biological systems (BioSystems) that cite the current articles. Citations are from the BioSystems source databases (KEGG and BioCyc).
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
Protein (RefSeq)
NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Protein Clusters
Clusters of related proteins from the Protein Clusters database that cite the current articles. Sources of references in Protein Clusters include the associated Gene and Conserved Domain records as well as NCBI added citations.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
GEO Profiles
Gene Expression Omnibus (GEO) Profiles of molecular abundance data. The current articles are references on the Gene record associated with the GEO profile.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

ppGpp: a global regulator in Escherichia coli.
ppGpp: a global regulator in Escherichia coli.
Trends Microbiol. 2005 May ;13(5):236-42.

PubMed
'Will you help me with my research?' Gaining access to primary care settings and...
'Will you help me with my research?' Gaining access to primary care settings and subjects.
Br J Gen Pract. 1992 Apr ;42(357):162-5.

PubMed
A brief but comprehensive lifestyle education program based on yoga reduces risk...
A brief but comprehensive lifestyle education program based on yoga reduces risk factors for cardiovascular disease and diabetes mellitus.
J Altern Complement Med. 2005 Apr ;11(2):267-74.

PubMed
Relationship between the working styles of general practitioners and the health ...
Relationship between the working styles of general practitioners and the health status of their patients.
Br J Gen Pract. 1992 Apr ;42(357):141-4.

PubMed
New mechanisms of skin innate immunity: ASK1-mediated keratinocyte differentiati...
New mechanisms of skin innate immunity: ASK1-mediated keratinocyte differentiation regulates the expression of beta-defensins, LL37, and TLR2.
Eur J Immunol. 2005 Jun ;35(6):1886-95.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: