Proc Natl Acad Sci U S A. 1992 May 15;89(10):4300-3.

Selection-induced mutations occur in yeast.

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Department of Biology, University of Rochester, NY 14627.

Abstract

Selection-induced mutations are nonrandom mutations that occur as specific and direct responses to environmental challenges and primarily in nondividing cells under conditions of intense prolonged selection. Selection-induced mutations have been shown to occur at six loci in Escherichia coli, but their existence has not previously been demonstrated in any eukaryotic organism. Here it is shown that selection-induced mutations occur at the HIS4 locus in the eukaryotic microorganism Saccharomyces cerevisiae.

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PMCID:: PMC49069

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