Genome Biol. 2005;6(4):215. Epub 2005 Mar 24.

Genomic studies of mood disorders -- the brain as a muscle?

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Institute of Psychiatric Research, Indiana University School of Medicine, 791 Union Drive, Indianapolis, IN 46202-4887, USA. anicules@iupui.edu

Abstract

Recent genomic studies showing abnormalities in the fibroblast growth factor system in the postmortem brains of people with major depressive disorder support previous indications of a role for growth factors in mood disorders. Similar molecular pathways, volumetric changes, and the effects of exercise on mood suggest a superficial analogy, and perhaps a deeper relationship, between muscle and brain functioning.

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PMCID: PMC1088952

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