Biosystems. 2005 May;80(2):175-84. Epub 2004 Dec 25.

The origin of the genetic code: theories and their relationships, a review.

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Institute of Genetics and Biophysics Adriano Buzzati-Traverso, CNR, Naples, Italy.

Abstract

A review of the main theories proposed to explain the origin of the genetic code is presented. I analyze arguments and data in favour of different theories proposed to explain the origin of the organization of the genetic code. It is possible to suggest a mechanism that makes compatible the different theories of the origin of the code, even if these are based on a historical or physicochemical determinism and thus appear incompatible by definition. Finally, I discuss the question of why a given number of synonymous codons was attributed to the amino acids in the genetic code.

PMID:: 15823416; [PubMed - indexed for MEDLINE]

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The origin of the genetic code: theories and their relationships, a review.

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