Crit Care. 2005 Apr;9(2):149-50. Epub 2005 Feb 28.

Blood flow, not hypoxia, determines intramucosal PCO2.

Source

Pulmonary and Critical Care Medicine Division, Department of Medicine, The George Washington University Medical Center, Washington, DC, USA. ggutierrez@mfa.gwu.edu

Abstract

Monitoring tissue hypoxia in critically ill patients is a challenging task. Tissue PCO2 has long been proposed as a marker of tissue hypoxia, although there is considerable controversy on whether the rise in CO2 with hypoxia is caused by anaerobic metabolism and excess CO2 production or by the accumulation of aerobically produced CO2 in the setting of blood flow stagnation. The prevention of increases in intestinal PCO2 in aggressively resuscitated septic animals supports the notion that tissue CO2 accumulation is a function of decreases in blood flow, not of tissue hypoxia.

PMID:: 15774068; [PubMed - indexed for MEDLINE]
PMCID: PMC1175940

Free PMC Article

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Molecular Biology Databases

Libraries

LinkOut Holdings

Supplemental Content

Related citations

Comparison of skeletal muscle PO2, PCO2, and pH with gastric tonometric P(CO2) and pH in hemorrhagic shock. [Crit Care Med. 1999]
Comparison of skeletal muscle PO2, PCO2, and pH with gastric tonometric P(CO2) and pH in hemorrhagic shock.
McKinley BA, Butler BD. Crit Care Med. 1999 Sep; 27(9):1869-77.
Intramucosal-arterial PCO2 gap fails to reflect intestinal dysoxia in hypoxic hypoxia. [Crit Care. 2002]
Intramucosal-arterial PCO2 gap fails to reflect intestinal dysoxia in hypoxic hypoxia.
Dubin A, Murias G, Estenssoro E, Canales H, Badie J, Pozo M, Sottile JP, Barán M, Pálizas F, Laporte M. Crit Care. 2002 Dec; 6(6):514-20. Epub 2002 Aug 28.
Increased blood flow prevents intramucosal acidosis in sheep endotoxemia: a controlled study. [Crit Care. 2005]
Increased blood flow prevents intramucosal acidosis in sheep endotoxemia: a controlled study.
Dubin A, Murias G, Maskin B, Pozo MO, Sottile JP, Barán M, Edul VS, Canales HS, Badie JC, Etcheverry G, et al. Crit Care. 2005 Apr; 9(2):R66-73. Epub 2005 Jan 11.
Review [Pathophysiology and strategy of shock in terms of tissue oxygen metabolism]. [Nihon Geka Gakkai Zasshi. 1999]
Review [Pathophysiology and strategy of shock in terms of tissue oxygen metabolism].
Sakio H, Ohtsu S, Ueno K. Nihon Geka Gakkai Zasshi. 1999 Oct; 100(10):663-6.
Review Gastric intramucosal pH: a noninvasive method for the indirect measurement of tissue oxygenation. [Am J Crit Care. 1992]
Review Gastric intramucosal pH: a noninvasive method for the indirect measurement of tissue oxygenation.
Clark CH, Gutierrez G. Am J Crit Care. 1992 Sep; 1(2):53-60.

See reviews... See all...

Chemical compound information

Carbon Dioxide

MW: 44.00 g/mol

MF: CO₂

See 42 citations for this compound....

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Free in PMC
Free full text articles in PMC

Recent activity

Clear Turn Off Turn On

Blood flow, not hypoxia, determines intramucosal PCO2.
Blood flow, not hypoxia, determines intramucosal PCO2.
Crit Care. 2005 Apr ;9(2):149-50. Epub 2005 Feb 28 .

PubMed
Pulse oximetry.
Pulse oximetry.
Crit Care. 1999 ;3(2):R11-R17.

PubMed
Thoracic epidural anesthesia in sepsis--is it harmful or protective?
Thoracic epidural anesthesia in sepsis--is it harmful or protective?
Crit Care. 2009 ;13(5):182. Epub 2009 Sep 16 .

PubMed
Target ranges and the apparent compliance with tight glycaemic control.
Target ranges and the apparent compliance with tight glycaemic control.
Anaesthesia. 2006 Oct ;61(10):956-8.

PubMed
Chaotic nature of sepsis and multiple organ failure cannot be explained by linea...
Chaotic nature of sepsis and multiple organ failure cannot be explained by linear statistical methods.
Crit Care. 2008 ;12(2):417. Epub 2008 Apr 22 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

Blood flow, not hypoxia, determines intramucosal PCO2.

Source

Abstract

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Molecular Biology Databases

Libraries

Supplemental Content

Related citations

Chemical compound information

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information