Immunology. 1992 Mar;75(3):553-4.

The role of interleukin-6 in vitamin A deficiency during Plasmodium falciparum malaria and possible consequences for vitamin A supplementation.

Tabone MD, Muanza K, Lyagoubi M, Jardel C, Pied S, Amedee-Manesme O, Grau GE, Mazier D.

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INSERM U 313, Hôpital de la Salpétrière, Paris, France.

Abstract

Kinetics of serum levels of interleukin-6 (IL-6) were studied in patients with acute Plasmodium falciparum malaria in relation to vitamin A and its binding proteins, retinol binding protein (RBP) and pre-albumin. It was found that IL-6 levels followed the rise and decrease of parasitaemia by 12 hr and correlated inversely with levels of vitamin A and its binding proteins. These data suggest that vitamin A supplementation alone might still be insufficient to restore a malaria-induced vitamin A deficiency.

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PMCID:: PMC1384755

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