Crit Care. 2005 Feb;9(1):37-44. Epub 2004 Sep 8.

Science review: The brain in sepsis--culprit and victim.

Sharshar T, Hopkinson NS, Orlikowski D, Annane D.

Source

Service de Réanimation Médicale, Hôpital Raymond Poincaré, Faculté de Médecine Paris Ile de France Ouest, Université de Versailles Saint-Quentin-en-Yvelines, Garches, France.

Abstract

On one side, brain dysfunction is a poorly explored complication of sepsis. On the other side, brain dysfunction may actively contribute to the pathogenesis of sepsis. The current review aimed at summarizing the current knowledge about the reciprocal interaction between the immune and central nervous systems during sepsis. The immune-brain cross talk takes part in circumventricular organs that, being free from blood-brain-barrier, interface between brain and bloodstream, in autonomic nuclei including the vagus nerve, and finally through the damaged endothelium. Recent observations have confirmed that sepsis is associated with excessive brain inflammation and neuronal apoptosis which clinical relevance remains to be explored. In parallel, damage within autonomic nervous and neuroendocrine systems may contribute to sepsis induced organ dysfunction.

PMID:: 15693982; [PubMed - indexed for MEDLINE]
PMCID: PMC1065096

Free PMC Article

Images from this publication.See all images (1) Free text

Publication Types, MeSH Terms

Publication Types

Review

MeSH Terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

IndexCopernicus

Medical

Libraries

LinkOut Holdings

Supplemental Content

Related citations

Review The encephalopathy in sepsis. [Crit Care Clin. 2008]
Review The encephalopathy in sepsis.
Siami S, Annane D, Sharshar T. Crit Care Clin. 2008 Jan; 24(1):67-82, viii.
Review [Brain injury during severe sepsis]. [Ann Fr Anesth Reanim. 2006]
Review [Brain injury during severe sepsis].
Leon A, Lepousé C, Floch T, Graftieaux JP. Ann Fr Anesth Reanim. 2006 Aug; 25(8):863-7. Epub 2006 May 11.
Review Sepsis associated encephalopathy (SAE): a review. [Front Biosci. 2004]
Review Sepsis associated encephalopathy (SAE): a review.
Green R, Scott LK, Minagar A, Conrad S. Front Biosci. 2004 May 1; 9:1637-41. Epub 2004 May 1.
Sepsis associated encephalopathy studied by MRI and cerebral spinal fluid S100B measurement. [Neurochem Res. 2009]
Sepsis associated encephalopathy studied by MRI and cerebral spinal fluid S100B measurement.
Piazza O, Cotena S, De Robertis E, Caranci F, Tufano R. Neurochem Res. 2009 Jul; 34(7):1289-92. Epub 2009 Jan 9.
Review Sepsis-associated delirium. [Intensive Care Med. 2007]
Review Sepsis-associated delirium.
Ebersoldt M, Sharshar T, Annane D. Intensive Care Med. 2007 Jun; 33(6):941-50. Epub 2007 Apr 5.

See reviews... See all...

Cited by 8 PubMed Central articles

Mechanisms of brain signaling during sepsis. [Curr Neuropharmacol. 2009]
Mechanisms of brain signaling during sepsis.
Akrout N, Sharshar T, Annane D. Curr Neuropharmacol. 2009 Dec; 7(4):296-301.
Review Cerebral perfusion in sepsis. [Crit Care. 2010]
Review Cerebral perfusion in sepsis.
Burkhart CS, Siegemund M, Steiner LA. Crit Care. 2010; 14(2):215. Epub 2010 Mar 9.
Multiscale model for the assessment of autonomic dysfunction in human endotoxemia. [Physiol Genomics. 2010]
Multiscale model for the assessment of autonomic dysfunction in human endotoxemia.
Foteinou PT, Calvano SE, Lowry SF, Androulakis IP. Physiol Genomics. 2010 Jun; 42(1):5-19. Epub 2010 Mar 16.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Science review: The brain in sepsis--culprit and victim.
Science review: The brain in sepsis--culprit and victim.
Crit Care. 2005 Feb ;9(1):37-44. Epub 2004 Sep 8 .

PubMed
Renal replacement strategies in the ICU.
Renal replacement strategies in the ICU.
Chest. 2007 Oct ;132(4):1379-88.

PubMed
Gastric versus duodenal feeding in patients with neurological disease: a pilot s...
Gastric versus duodenal feeding in patients with neurological disease: a pilot study.
J Neurosci Nurs. 2001 Jun ;33(3):148-9, 155-9.

PubMed
Acute necrotizing pancreatitis: treatment strategy according to the status of in...
Acute necrotizing pancreatitis: treatment strategy according to the status of infection.
Ann Surg. 2000 Nov ;232(5):619-26.

PubMed
Changes in skeletal muscle oxygenation during exercise measured by near-infrared...
Changes in skeletal muscle oxygenation during exercise measured by near-infrared spectroscopy on ascent to altitude.
Crit Care. 2009 ;13 Suppl 5:S7. Epub 2009 Nov 30 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: