J Infect Dis. 1992 May;165(5):957-60.

Interleukin-8 in cord sera: a sensitive and specific marker for the detection of preterm chorioamnionitis.

Shimoya K, Matsuzaki N, Taniguchi T, Jo T, Saji F, Kitajima H, Fujimura M, Nakayama M, Tanizawa O.

Source

Department of Obstetrics and Gynecology, Osaka University Medical School, Japan.

Abstract

Interleukin-8 (IL-8) exerts chemotactic activity on neutrophils at inflammatory sites to eliminate invading bacteria. To investigate whether the preterm fetus with chorioamnionitis produces IL-8, the titers of IL-8 were examined in sera of babies with (n = 38) and without chorioamnionitis (n = 34) using an EIA kit specific for IL-8. The infected babies had a significantly higher IL-8 titer than those not infected at 22-36 gestational weeks. The IL-8 titer was increased even in the mild histologic stage of chorioamnionitis and became much higher in the more severe stage. The IL-8 elevation, however, was remarkably suppressed by infusion of a steroid into the mother to promote fetal lung maturation. This retrospective study demonstrated that titration of IL-8 in cord serum is a more useful marker for the early detection of chorioamnionitis, because of its higher sensitivity and specificity, than conventional markers such as C-reactive protein.

PMID:: 1569349; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Medical

Molecular Biology Databases

BETAMETHASONE - HSDB

Libraries

LinkOut Holdings

Supplemental Content

Save items

Related citations in PubMed

Repeated courses of steroids in preterm membrane rupture do not increase the risk of histologic chorioamnionitis. [Am J Perinatol. 1997]
Repeated courses of steroids in preterm membrane rupture do not increase the risk of histologic chorioamnionitis.
Ghidini A, Salafia CM, Minior VK. Am J Perinatol. 1997 Jul; 14(6):309-13.
Histologic chorioamnionitis and umbilical serum levels of pro-inflammatory cytokines and cytokine inhibitors. [BJOG. 2002]
Histologic chorioamnionitis and umbilical serum levels of pro-inflammatory cytokines and cytokine inhibitors.
Døllner H, Vatten L, Halgunset J, Rahimipoor S, Austgulen R. BJOG. 2002 May; 109(5):534-9.
Umbilical cord blood concentrations of IL-6, IL-8, and MMP-8 in pregnancy complicated by preterm premature rupture of the membranes and histological chorioamnionitis. [Neuro Endocrinol Lett. 2010]
Umbilical cord blood concentrations of IL-6, IL-8, and MMP-8 in pregnancy complicated by preterm premature rupture of the membranes and histological chorioamnionitis.
Andrys C, Drahosova M, Hornychova H, Tambor V, Musilova I, Tosner J, Flidrova E, Kacerovsky M. Neuro Endocrinol Lett. 2010; 31(6):857-63.
Review [Complications and monitoring of the latency period after a preterm premature rupture of the fetal membranes: literature review]. [J Gynecol Obstet Biol Reprod (...]
Review [Complications and monitoring of the latency period after a preterm premature rupture of the fetal membranes: literature review].
Pasquier JC, Doret M. J Gynecol Obstet Biol Reprod (Paris). 2008 Oct; 37(6):568-78. Epub 2008 May 16.
Review Antimicrobial therapy in expectant management of preterm premature rupture of the membranes. [Lancet. 1995]
Review Antimicrobial therapy in expectant management of preterm premature rupture of the membranes.
Mercer BM, Arheart KL. Lancet. 1995 Nov 11; 346(8985):1271-9.

See reviews... See all...

Cited by 2 PubMed Central articles

Interleukin 8 (IL-8) - a universal biomarker? [Int Arch Med. 2010]
Interleukin 8 (IL-8) - a universal biomarker?
Shahzad A, Knapp M, Lang I, Köhler G. Int Arch Med. 2010 Jun 15; 3:11. Epub 2010 Jun 15.
Increase in interleukin-8 and soluble intercellular adhesion molecule-1 in bronchoalveolar lavage fluid from premature infants who develop chronic lung disease. [Arch Dis Child Fetal Neonatal ...]
Increase in interleukin-8 and soluble intercellular adhesion molecule-1 in bronchoalveolar lavage fluid from premature infants who develop chronic lung disease.
Kotecha S, Chan B, Azam N, Silverman M, Shaw RJ. Arch Dis Child Fetal Neonatal Ed. 1995 Mar; 72(2):F90-6.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Interleukin-8 in cord sera: a sensitive and specific marker for the detection of...
Interleukin-8 in cord sera: a sensitive and specific marker for the detection of preterm chorioamnionitis.
J Infect Dis. 1992 May ;165(5):957-60.

PubMed
Shisa promotes head formation through the inhibition of receptor protein maturat...
Shisa promotes head formation through the inhibition of receptor protein maturation for the caudalizing factors, Wnt and FGF.
Cell. 2005 Jan 28 ;120(2):223-35.

PubMed
Demand and need for treatment of craniomandibular dysfunction in the Dutch adult...
Demand and need for treatment of craniomandibular dysfunction in the Dutch adult population.
J Dent Res. 1992 Sep ;71(9):1607-12.

PubMed
Annual report to the nation on the status of cancer, 1975-2001, with a special f...
Annual report to the nation on the status of cancer, 1975-2001, with a special feature regarding survival.
Cancer. 2004 Jul 1 ;101(1):3-27.

PubMed
Right and left ventricular functional impairment and sleep apnea.
Right and left ventricular functional impairment and sleep apnea.
Clin Chest Med. 1992 Sep ;13(3):459-79.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Interleukin-8 in cord sera: a sensitive and specific marker for the detection of preterm chorioamnionitis.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Molecular Biology Databases

Libraries

Supplemental Content

Save items

Related citations in PubMed

Cited by 2 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information