Acc Chem Res. 2005 Jan;38(1):62-9.

How to hide zinc in a small protein.

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School of Chemistry, University of Edinburgh, West Mains Road, Edinburgh EH9 3JJ, UK.

Abstract

Small cysteine-rich proteins (metallothioneins) and related domains of some large proteins (e.g., lysine methyltransferases) bind tri- and tetranuclear zinc clusters with topologies resembling fragments of Zn(II) sulfide minerals. These clusters are ubiquitous in animals, plants, and bacteria. Bacterial metallothioneins can also contain histidines as cluster ligands and embed Zn(II) with a "treble-clef"-like finger fold. This unusual embedded Zn(II) is "hidden" and surprisingly inert toward Zn or Cd exchange. Clearly, proteins can exert fine control over both the thermodynamics and kinetics of zinc binding in thiolate clusters. Genome sequences suggest that related zinc-finger sites are common in a variety of bacteria.

PMID:: 15654738; [PubMed - indexed for MEDLINE]

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