Warning: The NCBI web site requires JavaScript to function. more...

My NCBI Sign In

Result Filters

BMC Biol. 2004 Dec 2;2:25.

Search for computational modules in the C. elegans brain.

Reigl M, Alon U, Chklovskii DB.

Source

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA. markus.reigl@gmx.net <markus.reigl@gmx.net>

Abstract

BACKGROUND:

Does the C. elegans nervous system contain multi-neuron computational modules that perform stereotypical functions? We attempt to answer this question by searching for recurring multi-neuron inter-connectivity patterns in the C. elegans nervous system's wiring diagram.

RESULTS:

Our statistical analysis reveals that some inter-connectivity patterns containing two, three and four (but not five) neurons are significantly over-represented relative to the expectations based on the statistics of smaller inter-connectivity patterns.

CONCLUSIONS:

Over-represented patterns (or motifs) are candidates for computational modules that may perform stereotypical functions in the C. elegans nervous system. These modules may appear in other species and need to be investigated further.

PMID:: 15574204; [PubMed - indexed for MEDLINE]
PMCID:: PMC539283

Free PMC Article

Images from this publication.See all images (7) Free text

Publication Types, MeSH Terms

Publication Types

Research Support, Non-U.S. Gov't

MeSH Terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Libraries

LinkOut Holdings

Supplemental Content

Icon for BioMed Central

Icon for PubMed Central

Save items

loading

Related citations in PubMed

Computational inference of the molecular logic for synaptic connectivity in C. elegans. [Bioinformatics. 2006]
Computational inference of the molecular logic for synaptic connectivity in C. elegans.
Varadan V, Miller DM 3rd, Anastassiou D. Bioinformatics. 2006 Jul 15; 22(14):e497-506.
Structural properties of the Caenorhabditis elegans neuronal network. [PLoS Comput Biol. 2011]
Structural properties of the Caenorhabditis elegans neuronal network.
Varshney LR, Chen BL, Paniagua E, Hall DH, Chklovskii DB. PLoS Comput Biol. 2011 Feb 3; 7(2):e1001066. Epub 2011 Feb 3.
Topological cluster analysis reveals the systemic organization of the Caenorhabditis elegans connectome. [PLoS Comput Biol. 2011]
Topological cluster analysis reveals the systemic organization of the Caenorhabditis elegans connectome.
Sohn Y, Choi MK, Ahn YY, Lee J, Jeong J. PLoS Comput Biol. 2011 May; 7(5):e1001139. Epub 2011 May 19.
Review Deciphering the neural and molecular mechanisms of C. elegans behavior. [Curr Biol. 2005]
Review Deciphering the neural and molecular mechanisms of C. elegans behavior.
Schafer WR. Curr Biol. 2005 Sep 6; 15(17):R723-9.
Review Glia-neuron interactions in the nervous system of Caenorhabditis elegans. [Curr Opin Neurobiol. 2006]
Review Glia-neuron interactions in the nervous system of Caenorhabditis elegans.
Shaham S. Curr Opin Neurobiol. 2006 Oct; 16(5):522-8. Epub 2006 Aug 28.

See reviews... See all...

Cited by 11 PubMed Central articles

Topological cluster analysis reveals the systemic organization of the Caenorhabditis elegans connectome. [PLoS Comput Biol. 2011]
Topological cluster analysis reveals the systemic organization of the Caenorhabditis elegans connectome.
Sohn Y, Choi MK, Ahn YY, Lee J, Jeong J. PLoS Comput Biol. 2011 May; 7(5):e1001139. Epub 2011 May 19.
Colored motifs reveal computational building blocks in the C. elegans brain. [PLoS One. 2011]
Colored motifs reveal computational building blocks in the C. elegans brain.
Qian J, Hintze A, Adami C. PLoS One. 2011 Mar 7; 6(3):e17013. Epub 2011 Mar 7.
Structural properties of the Caenorhabditis elegans neuronal network. [PLoS Comput Biol. 2011]
Structural properties of the Caenorhabditis elegans neuronal network.
Varshney LR, Chen BL, Paniagua E, Hall DH, Chklovskii DB. PLoS Comput Biol. 2011 Feb 3; 7(2):e1001066. Epub 2011 Feb 3.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Search for computational modules in the C. elegans brain.
Search for computational modules in the C. elegans brain.
BMC Biol. 2004 Dec 2 ;2:25.

PubMed
Analysis of gene expression in single live neurons.
Analysis of gene expression in single live neurons.
Proc Natl Acad Sci U S A. 1992 Apr 1 ;89(7):3010-4.

PubMed
Evaluation of Australia's National Notifiable Disease Surveillance System.
Evaluation of Australia's National Notifiable Disease Surveillance System.
Commun Dis Intell. 2004 ;28(3):311-23.

PubMed
Nucleoplasmic localization of prelamin A: implications for prenylation-dependent...
Nucleoplasmic localization of prelamin A: implications for prenylation-dependent lamin A assembly into the nuclear lamina.
Proc Natl Acad Sci U S A. 1992 Apr 1 ;89(7):3000-4.

PubMed
Effects of aerobic and strength exercise on motor fatigue in men and women with ...
Effects of aerobic and strength exercise on motor fatigue in men and women with multiple sclerosis: a randomized controlled trial.
Clin Rehabil. 2004 Nov ;18(7):737-46.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...

You are here: NCBI > Literature > PubMed

Write to the Help Desk