J Rheumatol. 1992 Jan;19(1):22-5.

Serial estimation of interleukin 6 as a measure of systemic disease in rheumatoid arthritis.

Dasgupta B, Corkill M, Kirkham B, Gibson T, Panayi G.

Source

Rheumatology Unit, United Medical School, Guy's Hospital, London, UK.

Abstract

Disease activity in rheumatoid arthritis (RA) is frequently associated with a marked acute phase response, thrombocytosis, hypergammaglobulinemia and the presence of rheumatoid factors (RF). Interleukin 6 (IL-6) is a cytokine that stimulates hepatocytes to produce acute phase reactants and B lymphocytes to produce immunoglobulin. We measured serum IL-6 in patients with active RA during induction of intramuscular gold therapy. Levels of IL-6 correlated strongly with the erythrocyte sedimentation rate and RF titers and to a lesser degree with platelet counts. It may, therefore, be responsible for many of the systemic manifestations of RA and its measurement in the serum may be a convenient and reproducible variable for the assessment of disease activity in this very common disease.

Comment in

J Rheumatol. 1993 Jul;20(7):1253-5.

PMID:: 1556695; [PubMed - indexed for MEDLINE]

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