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    Antimicrob Agents Chemother. 2004 Nov;48(11):4422-6.

    Dose-dependent resorption of quinine after intrarectal administration to children with moderate Plasmodium falciparum malaria.

    Pussard E, Straczek C, Kaboré I, Bicaba A, Balima-Koussoube T, Bouree P, Barennes H.

    Source

    Service de Pharmacologie, Hôpital de Bicêtre, 78 rue du Général Leclerc, 94275 Le Kremlin-Bicêtre, France. eric.pussard@bct.ap-hop-paris.fr

    Abstract

    The pharmacokinetics of increasing doses of an intrarectal Cinchona alkaloid combination containing 96.1% quinine, 2.5% quinidine, 0.68% cinchonine, and 0.67% cinchonidine (Quinimax) was compared to that of parenteral regimens in 60 children with moderate malaria. Quinine exhibited a nonlinear pharmacokinetics, suggesting a saturation of rectal resorption. When early rejections appeared, blood quinine concentrations decreased by 30 to 50% and were restored by an immediate half-dose administration of the drug. Rectal administration of doses of 16 or 20 mg/kg of body weight led to concentration-time profiles in blood similar to those of parenteral regimens and could be an early treatment of childhood malaria.

    PMID:
    15504872
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC525409
    Free PMC Article

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