Mol Psychiatry. 2005 Jun;10(6):545-52.

A genome-wide scan points to a susceptibility locus for bipolar disorder on chromosome 12.

Shink E, Morissette J, Sherrington R, Barden N.

Source

Neuroscience, CHUL Research Centre and Laval University, CHUQ Pavillon CHUL, Ste-Foy, Québec, Canada.

Abstract

Our previous results pointed to a putative gene for susceptibility to bipolar affective disorder located on the chromosomal region 12q23-q24 that segregated in the Saguenay-Lac-St-Jean population of Quebec. We report here results from a second genome-wide scan based on the analysis of 380 polymorphic microsatellite markers. For the purpose of this analysis, an additional 18 families were recruited from the Saguenay-Lac-St-Jean region and pooled to our previous sample to improve its statistical power, giving a total of 394 sampled individuals. This work confirms the presence of a susceptibility locus for affective disorder on chromosome 12q24 with parametric LOD score value of 3.35 at D12S378 when pedigrees were broken into nuclear families and analysed under a recessive segregation model. This result was supported by neighbouring markers and by a LOD score value of 5.05 at D12S378 under model-free analysis. Other regions of lower interest were indicated on chromosomes 2, 5, 7, 9, 10, 17 and 20.

PMID:: 15494705; [PubMed - indexed for MEDLINE]

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Genome-wide search for linkage of bipolar affective disorders in a very large pedigree derived from a homogeneous population in quebec points to a locus of major effect on chromosome 12q23-q24. [Am J Med Genet. 1999]
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