Science. 1992 Feb 21;255(5047):991-4.

Vegetal messenger RNA localization directed by a 340-nt RNA sequence element in Xenopus oocytes.

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Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, MA 02138.

Abstract

Contained within a single cell, the fertilized egg, is information that will ultimately specify the entire organism. During early embryonic cleavages, cells acquire distinct fates and their differences in developmental potential might be explained by localization of informational molecules in the egg. The mechanisms by which Vg1 RNA, a maternal mRNA, is translocated to the vegetal pole of Xenopus oocytes may indicate how developmental signals are localized. Data presented here show that a 340-nucleotide localization signal present in the 3' untranslated region of Vg1 RNA is sufficient to direct RNA localization to the vegetal pole.

PMID:: 1546297; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

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MeSH Terms

Substances

RNA, Messenger

Grant Support

GM 32921/GM/NIGMS NIH HHS/United States

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