J Biol Chem. 1992 Mar 5;267(7):4999-5004.

Functional regulation of osteoblastic cells by the interaction of activin-A with follistatin.

Hashimoto M, Shoda A, Inoue S, Yamada R, Kondo T, Sakurai T, Ueno N, Muramatsu M.

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Department of Biochemistry, Faculty of Medicine, University of Tokyo, Japan.

Abstract

A high number of 125I-activin-A binding sites (an apparent Kd of 260 pM and 5,600 sites/cell) were observed on MC3T3-E1 cells, a well characterized osteoblastic cell line. Activin-A has a mitogenic effect on these cells, with the greatest influence being observed on cells in an undifferentiated state, as well as a suppressive effect on the alkaline phosphatase activity. Northern and ligand blotting analyses revealed that these osteoblastic cells produce follistatin, which was down-regulated by retinoic acid treatment. Because follistatin is an activin-A-binding protein, we suggest that activin-A modulates the function of osteoblastic cells by being regulated by follistatin during differentiation.

PMID:: 1537876; [PubMed - indexed for MEDLINE]

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