Nature. 2004 Sep 16;431(7006):350-5.

The functions of animal microRNAs.

Source

Dartmouth Medical School, Department of Genetics, Hanover, New Hampshire 03755, USA (e-mail: vra@dartmouth.edu)

Abstract

MicroRNAs (miRNAs) are small RNAs that regulate the expression of complementary messenger RNAs. Hundreds of miRNA genes have been found in diverse animals, and many of these are phylogenetically conserved. With miRNA roles identified in developmental timing, cell death, cell proliferation, haematopoiesis and patterning of the nervous system, evidence is mounting that animal miRNAs are more numerous, and their regulatory impact more pervasive, than was previously suspected.

PMID:: 15372042; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

MicroRNAs

LinkOut - more resources

Full Text Sources

Other Literature Sources

Libraries

LinkOut Holdings

Supplemental Content

Related citations

Review Small but influential: the role of microRNAs on gene regulatory network and 3'UTR evolution. [J Genet Genomics. 2009]
Review Small but influential: the role of microRNAs on gene regulatory network and 3'UTR evolution.
Zhang R, Su B. J Genet Genomics. 2009 Jan; 36(1):1-6.
Conservation and divergence of microRNAs in Populus. [BMC Genomics. 2007]
Conservation and divergence of microRNAs in Populus.
Barakat A, Wall PK, Diloreto S, Depamphilis CW, Carlson JE. BMC Genomics. 2007 Dec 31; 8:481. Epub 2007 Dec 31.
Identification and characterization of new microRNAs from pig. [Mamm Genome. 2008]
Identification and characterization of new microRNAs from pig.
Kim J, Cho IS, Hong JS, Choi YK, Kim H, Lee YS. Mamm Genome. 2008 Aug; 19(7-8):570-80. Epub 2008 Jun 12.
Drosophila microRNAs exhibit diverse spatial expression patterns during embryonic development. [Proc Natl Acad Sci U S A. 2005]
Drosophila microRNAs exhibit diverse spatial expression patterns during embryonic development.
Aboobaker AA, Tomancak P, Patel N, Rubin GM, Lai EC. Proc Natl Acad Sci U S A. 2005 Dec 13; 102(50):18017-22. Epub 2005 Dec 5.
Review Embryonic stem cell microRNAs: defining factors in induced pluripotent (iPS) and cancer (CSC) stem cells? [Curr Stem Cell Res Ther. 2009]
Review Embryonic stem cell microRNAs: defining factors in induced pluripotent (iPS) and cancer (CSC) stem cells?
Gunaratne PH. Curr Stem Cell Res Ther. 2009 Sep; 4(3):168-77.

See reviews... See all...

Cited by over 100 PubMed Central articles

Exploiting the Interplay between Innate and Adaptive Immunity to Improve Immunotherapeutic Strategies for Epstein-Barr-Virus-Driven Disorders. [Clin Dev Immunol. 2012]
Exploiting the Interplay between Innate and Adaptive Immunity to Improve Immunotherapeutic Strategies for Epstein-Barr-Virus-Driven Disorders.
Martorelli D, Muraro E, Merlo A, Turrini R, Faè DA, Rosato A, Dolcetti R. Clin Dev Immunol. 2012; 2012:931952. Epub 2012 Jan 29.
microRNA Response to Listeria monocytogenes Infection in Epithelial Cells. [Int J Mol Sci. 2012]
microRNA Response to Listeria monocytogenes Infection in Epithelial Cells.
Izar B, Mannala GK, Mraheil MA, Chakraborty T, Hain T. Int J Mol Sci. 2012; 13(1):1173-85. Epub 2012 Jan 20.
A New Strategy for Identification of Highly Conserved microRNAs in Non-Model Insect, Spodoptera litura. [Int J Mol Sci. 2012]
A New Strategy for Identification of Highly Conserved microRNAs in Non-Model Insect, Spodoptera litura.
Gao L, Zuo H, Liu K, Li H, Zhong G. Int J Mol Sci. 2012; 13(1):612-27. Epub 2012 Jan 9.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

The functions of animal microRNAs.
The functions of animal microRNAs.
Nature. 2004 Sep 16 ;431(7006):350-5.

PubMed
Changes in microRNA expression profiles in HIV-1-transfected human cells.
Changes in microRNA expression profiles in HIV-1-transfected human cells.
Retrovirology. 2005 Dec 28 ;2:81.

PubMed
In situ detection of Gag-specific CD8+ cells in the GI tract of SIV infected Rhe...
In situ detection of Gag-specific CD8+ cells in the GI tract of SIV infected Rhesus macaques.
Retrovirology. 2010 Feb 16 ;7:12.

PubMed
Apoptotic death of striatal neurons induced by human immunodeficiency virus-1 Ta...
Apoptotic death of striatal neurons induced by human immunodeficiency virus-1 Tat and gp120: Differential involvement of caspase-3 and endonuclease G.
J Neurovirol. 2004 Jun ;10(3):141-51.

PubMed
Citation advantage of open access articles.
Citation advantage of open access articles.
PLoS Biol. 2006 May ;4(5):e157. Epub 2006 May 16 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: