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    J Virol. 1992 Jun;66(6):3961-5.

    Activation of the human immunodeficiency virus type 1 enhancer is not dependent on NFAT-1.

    Source

    Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109-0650.

    Abstract

    The function of a putative NFAT-1 site in the human immunodeficiency virus type 1 enhancer has been analyzed. Activation by the T-cell antigen receptor is minimal in Jurkat cells and is mediated by the kappa B sites. The putative NFAT-1 region is not required for the response to anti-CD3 or to mitogens in T-cell, B-cell, or monocyte/macrophage leukemia lines, nor is it a cis-acting negative regulatory element.

    PMID:
    1533884
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC241190
    Free PMC Article

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